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1G244

Name: 1G244
Brand: TargetMol
SKU: T14005
Price: 283 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T14005Cas No. 847928-32-9

1G244 is an inhibitor of DPP8/9 with antiatherosclerotic and antimyeloma properties. 1G244 had the IC50 values of 14 and 53 nM against DPP8 and DPP9, and The Ki values for 1G244 were 0.9 and 4.2 nM for DPP8 and DPP9

1G244

🥰Excellent

Purity: 99.14%

Catalog No. T14005Cas No. 847928-32-9

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$33	In Stock	In Stock
10 mg	$53	In Stock	In Stock
25 mg	$106	In Stock	In Stock
50 mg	$173	In Stock	In Stock
100 mg	$283	-	In Stock
500 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.14%

ee:98.76%

Resource Download

COA HPLC HNMR CSFC

Product Introduction

Bioactivity

Description	1G244 is an inhibitor of DPP8/9 with antiatherosclerotic and antimyeloma properties. 1G244 had the IC50 values of 14 and 53 nM against DPP8 and DPP9, and The Ki values for 1G244 were 0.9 and 4.2 nM for DPP8 and DPP9
Targets&IC50	DPP8:14 nM, DPP8:0.9 nM(ki), DPP9:4.2 nM(ki), DPP9:53 nM
In vitro	1G244 (0-100 μM) dose-dependently decreased viable cell number of five multiple myeloma cell lines as well as three T-cell lymphoma cell lines[2].
In vivo	The apoE−/− mice treated with 1G244 (1G244 dissolved in 75% PEG 300, 2 mg/kg) showed that 1G244 reduced the area of advanced atherosclerotic lesions by about 14%[1]. 1G244 was administered subcutaneously into mice at 30 mg/kg once a week, administration of 1G244 apparently suppressed the subcutaneous growth of MM.1 S cells[2].

Chemical Properties

Molecular Weight	504.57
Formula	C₂₉H₃₀F₂N₄O₂
Cas No.	847928-32-9
Smiles	N[C@@H](CC(=O)N1CCN(CC1)C(c1ccc(F)cc1)c1ccc(F)cc1)C(=O)N1Cc2ccccc2C1
Relative Density.	1.304 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 225 mg/mL (445.92 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (9.91 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9819 mL	9.9094 mL	19.8189 mL	99.0943 mL
5 mM	0.3964 mL	1.9819 mL	3.9638 mL	19.8189 mL
10 mM	0.1982 mL	0.9909 mL	1.9819 mL	9.9094 mL
20 mM	0.0991 mL	0.4955 mL	0.9909 mL	4.9547 mL
50 mM	0.0396 mL	0.1982 mL	0.3964 mL	1.9819 mL
100 mM	0.0198 mL	0.0991 mL	0.1982 mL	0.9909 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc