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Ensitrelvir fumarate
(Synonyms: S-217622 fumarate) Copy Product Info
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Synonyms: S-217622 fumarate
Catalog No. T40358 Copy Product Info
🥰Excellent
Ensitrelvir (S-217622) fumarate is a novel orally active inhibitor targeting the SARS-CoV-2 3CL protease (IC50 = 13 nM), demonstrating non-covalent and non-peptidic characteristics. This compound represents a pioneering advancement in the development of effective antiviral agents against the SARS-CoV-2 virus.
Cas No. 2757470-18-9
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 2 mg | $53 | 5 days | 5 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Ensitrelvir (S-217622) fumarate is a novel orally active inhibitor targeting the SARS-CoV-2 3CL protease (IC50 = 13 nM), demonstrating non-covalent and non-peptidic characteristics. This compound represents a pioneering advancement in the development of effective antiviral agents against the SARS-CoV-2 virus. |
| In vitro | In a cytopathic effect (cpe)-inhibition assay on VeroE6/TMPRSS2 cells infected with SARS-CoV-2, Ensitrelvir fumarate demonstrated EC50 values of approximately 0.4 μM for the wild-type virus and the Alpha, Beta, Gamma, and Delta variants, and EC50 values of 0.21 μM and 1.4 μM for SARS-CoV and MERS-CoV, respectively[1]. |
| In vivo | Ensitrelvir fumarate effectively reduces SARS-CoV-2 replication within the lungs of mice in a dose-dependent manner[2]. |
| Synonyms | S-217622 fumarate |
| Molecular Weight | 647.96 |
| Formula | C26H21ClF3N9O6 |
| Cas No. | 2757470-18-9 |
| Smiles | OC(=O)\C=C\C(O)=O.Cn1cnc(Cn2c(=O)[nH]c(=Nc3cc4cn(C)nc4cc3Cl)n(Cc3cc(F)c(F)cc3F)c2=O)n1 |w:19.18| |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: Ensitrelvir fumarate chemical structure | Ensitrelvir fumarate in vivo | Ensitrelvir fumarate in vitro | Ensitrelvir fumarate formula | Ensitrelvir fumarate molecular weight
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