Ensitrelvir fumarate

Name: Ensitrelvir fumarate
Brand: TargetMol
SKU: T40358
Rating: 4.5 (1 reviews)

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Catalog No. T40358Cas No. 2757470-18-9

Alias S-217622 fumarate

Ensitrelvir (S-217622) fumarate is a novel orally active inhibitor targeting the SARS-CoV-2 3CL protease (IC50 = 13 nM), demonstrating non-covalent and non-peptidic characteristics. This compound represents a pioneering advancement in the development of effective antiviral agents against the SARS-CoV-2 virus.

Ensitrelvir fumarate

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Catalog No. T40358Alias S-217622 fumarateCas No. 2757470-18-9

Pack Size	Price	Availability	Quantity
2 mg	$53	5 days

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Product Introduction

Bioactivity

Description	Ensitrelvir (S-217622) fumarate is a novel orally active inhibitor targeting the SARS-CoV-2 3CL protease (IC50 = 13 nM), demonstrating non-covalent and non-peptidic characteristics. This compound represents a pioneering advancement in the development of effective antiviral agents against the SARS-CoV-2 virus.
In vitro	In a cytopathic effect (cpe)-inhibition assay on VeroE6/TMPRSS2 cells infected with SARS-CoV-2, Ensitrelvir fumarate demonstrated EC50 values of approximately 0.4 μM for the wild-type virus and the Alpha, Beta, Gamma, and Delta variants, and EC50 values of 0.21 μM and 1.4 μM for SARS-CoV and MERS-CoV, respectively[1].
In vivo	Ensitrelvir fumarate effectively reduces SARS-CoV-2 replication within the lungs of mice in a dose-dependent manner[2].
Synonyms	S-217622 fumarate

Chemical Properties

Molecular Weight	647.96
Formula	C₂₆H₂₁ClF₃N₉O₆
Cas No.	2757470-18-9
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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