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AZ-PFKFB3-67

Name: AZ-PFKFB3-67
Brand: TargetMol
SKU: T26730
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T26730Cas No. 1704741-11-6

Alias AZPFKFB3-67, AZ-PFKFB367

AZ-PFKFB3-67 is a potent and selective PFKFB3 kinase inhibitor with an IC50=11nM for PFKFB3, reduces MCL-1, and inhibits angiogenesis by decreasing lactic acid production and ATP levels in endothelial cells (ECs) in tube-forming assays, and has neuroprotective effects.

AZ-PFKFB3-67

🥰Excellent

Purity: 99.79%

Catalog No. T26730Alias AZPFKFB3-67, AZ-PFKFB367Cas No. 1704741-11-6

Pack Size	Price	Availability
1 mg	$44	In Stock
5 mg	$98	In Stock
10 mg	$163	In Stock
25 mg	$295	In Stock
50 mg	$437	In Stock
100 mg	$646	In Stock
200 mg	$952	In Stock
1 mL x 10 mM (in DMSO)	$113	In Stock

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Purity:99.79%

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COA LCMS HNMR

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Product Introduction

Bioactivity

Description	AZ-PFKFB3-67 is a potent and selective PFKFB3 kinase inhibitor with an IC50=11nM for PFKFB3, reduces MCL-1, and inhibits angiogenesis by decreasing lactic acid production and ATP levels in endothelial cells (ECs) in tube-forming assays, and has neuroprotective effects.
Targets&IC50	PFKFB2:159 nM, PFKFB1:1130 nM, PFKFB3:11 nM, Intracellular F-2,6-BP production:0.281 μM
In vitro	AZ-PFKFB3-67 is a highly selective PFKFB3 inhibitor with strong target inhibitory activity, exhibiting IC₅₀ values of 1.13 μM for PFKFB1, 0.159 μM for PFKFB2, and 0.011 μM for PFKFB3. In cellular assays, AZ-PFKFB3-67 inhibits fructose-2,6-bisphosphate (F-2,6-BP) production with an IC₅₀ of 0.281 μM, while having minimal effect on cellular lactate levels (IC₅₀ > 30 μM), indicating a pronounced inhibitory effect on early glycolytic regulation[1].
Alias	AZPFKFB3-67, AZ-PFKFB367

Chemical Properties

Molecular Weight	455.51
Formula	C₂₆H₂₅N₅O₃
Cas No.	1704741-11-6
Smiles	C(#N)C=1C=2C(N(CC=3C(C)=NOC3C)C1)=CC=C(OC4=CC=C(NC(=O)[C@@H]5CCCN5)C=C4)C2
Relative Density.	1.34 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (175.63 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1953 mL	10.9767 mL	21.9534 mL	109.7671 mL
5 mM	0.4391 mL	2.1953 mL	4.3907 mL	21.9534 mL
10 mM	0.2195 mL	1.0977 mL	2.1953 mL	10.9767 mL
20 mM	0.1098 mL	0.5488 mL	1.0977 mL	5.4884 mL
50 mM	0.0439 mL	0.2195 mL	0.4391 mL	2.1953 mL
100 mM	0.0220 mL	0.1098 mL	0.2195 mL	1.0977 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc