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XRP44X (Synonyms: XRP-44-X, XRP-44X, XRP 44X, XRP 44 X)

Name: XRP44X
Brand: TargetMol
SKU: T20759
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T20759 Copy Product Info

Purity: 99.67%

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XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.

XRP44X

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Catalog No. T20759

Synonyms XRP-44-X, XRP-44X, XRP 44X, XRP 44 X

XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.

Cas No. 729605-21-4

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Pack Size	Price	USA Stock	Global Stock
10 mg	$50	In Stock	In Stock
25 mg	$73	In Stock	In Stock
50 mg	$113	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$51	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.67%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.
Targets&IC50	Ras:10 nM
In vitro	XRP44X is an indirect inhibitor of Net phosphorylation, acting upstream of Erk-1/2 activation. XRP44X inhibits luciferase activity with an IC50 of approximately 10 nM[1]. At 10 nM, XRP44X inhibits the growth of HUVEC, NIH3T3, HCT-116, and NIH3T3–Ki-Ras cells[1]. At 100 nM, it inhibits phosphorylation of Mek-1/2 and Raf-1[1].
In vivo	XRP44X, an inhibitor of Ras/Erk activation of the transcription factor Elk3, demonstrates therapeutic potential for refractory asthma[1] by reducing tumor growth and metastasis in nude mice[2].
Synonyms	XRP-44-X, XRP-44X, XRP 44X, XRP 44 X

Chemical Properties

Molecular Weight	380.87
Formula	C₂₁H₂₁ClN₄O
Cas No.	729605-21-4
Smiles	C(=O)(C=1N(N=C(C)C1)C2=CC=CC=C2)N3CCN(CC3)C4=CC(Cl)=CC=C4
Relative Density.	1.27 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 36.67 mg/mL (96.28 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6256 mL	13.1278 mL	26.2557 mL	131.2784 mL
5 mM	0.5251 mL	2.6256 mL	5.2511 mL	26.2557 mL
10 mM	0.2626 mL	1.3128 mL	2.6256 mL	13.1278 mL
20 mM	0.1313 mL	0.6564 mL	1.3128 mL	6.5639 mL
50 mM	0.0525 mL	0.2626 mL	0.5251 mL	2.6256 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc