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XRP44X

Name: XRP44X
Brand: TargetMol
SKU: T20759
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20759Cas No. 729605-21-4

Alias XRP-44-X, XRP-44X, XRP 44X, XRP 44 X

XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.

XRP44X

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Purity: 99.67%

Catalog No. T20759Alias XRP-44-X, XRP-44X, XRP 44X, XRP 44 XCas No. 729605-21-4

XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.

Pack Size	Price	Availability
10 mg	$50	In Stock
25 mg	$73	In Stock
50 mg	$113	In Stock
1 mL x 10 mM (in DMSO)	$51	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.67%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway.
Targets&IC50	Ras:10 nM
In vitro	XRP44X is an indirect inhibitor of Net phosphorylation, acting upstream of Erk-1/2 activation. XRP44X inhibits luciferase activity with an IC50 of approximately 10 nM[1]. At 10 nM, XRP44X inhibits the growth of HUVEC, NIH3T3, HCT-116, and NIH3T3–Ki-Ras cells[1]. At 100 nM, it inhibits phosphorylation of Mek-1/2 and Raf-1[1].
In vivo	XRP44X, an inhibitor of Ras/Erk activation of the transcription factor Elk3, demonstrates therapeutic potential for refractory asthma[1] by reducing tumor growth and metastasis in nude mice[2].
Synonyms	XRP-44-X, XRP-44X, XRP 44X, XRP 44 X

Chemical Properties

Molecular Weight	380.87
Formula	C₂₁H₂₁ClN₄O
Cas No.	729605-21-4
Smiles	C(=O)(C=1N(N=C(C)C1)C2=CC=CC=C2)N3CCN(CC3)C4=CC(Cl)=CC=C4
Relative Density.	1.27 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 36.67 mg/mL (96.28 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6256 mL	13.1278 mL	26.2557 mL	131.2784 mL
5 mM	0.5251 mL	2.6256 mL	5.2511 mL	26.2557 mL
10 mM	0.2626 mL	1.3128 mL	2.6256 mL	13.1278 mL
20 mM	0.1313 mL	0.6564 mL	1.3128 mL	6.5639 mL
50 mM	0.0525 mL	0.2626 mL	0.5251 mL	2.6256 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc