Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EFdA-TP tetrasodium, a potent nucleoside reverse transcriptase (RT) inhibitor, effectively halts RT-catalyzed DNA synthesis by acting as an immediate or delayed chain terminator (ICT or DCT). It employs multiple mechanisms to inhibit HIV-1 RT [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 2,270.00 | |
50 mg | 10-14 weeks | $ 2,980.00 | |
100 mg | 10-14 weeks | $ 4,000.00 |
Description | EFdA-TP tetrasodium, a potent nucleoside reverse transcriptase (RT) inhibitor, effectively halts RT-catalyzed DNA synthesis by acting as an immediate or delayed chain terminator (ICT or DCT). It employs multiple mechanisms to inhibit HIV-1 RT [1]. |
In vitro | EFdA-TP tetrasodium, at concentrations ranging from 0.05-10 μM and applied for 15 minutes, acts as a translocation-defective reverse transcriptase (RT) inhibitor, significantly hindering RT-catalyzed DNA synthesis. It operates both as an immediate chain terminator (ICT) and as a delayed chain terminator (DCT), allowing for the insertion of one more deoxynucleotide triphosphate (dNTP) before effectively halting DNA synthesis [1]. |
Molecular Weight | 621.12 |
Formula | C12H11FN5Na4O12P3 |
CAS No. | 2883783-00-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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EFdA-TP tetrasodium 2883783-00-2 Microbiology/Virology Reverse Transcriptase inhibitor inhibit