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Thiamine hydrochloride

Name: Thiamine hydrochloride
Brand: TargetMol
SKU: T0894
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0894Cas No. 67-03-8

Alias Vitamin B1 hydrochloride, Thiamine HCl, Thiamine chloride hydrochloride

Thiamine hydrochloride (Vitamin B1) is an essential micronutrient and a cofactor for many central metabolic enzymes.

Thiamine hydrochloride

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Purity: 99.96%

Catalog No. T0894Alias Vitamin B1 hydrochloride, Thiamine HCl, Thiamine chloride hydrochlorideCas No. 67-03-8

Thiamine hydrochloride (Vitamin B1) is an essential micronutrient and a cofactor for many central metabolic enzymes.

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$33	In Stock	In Stock
1 g	$42	In Stock	In Stock
2 g	$59	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.96%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Thiamine hydrochloride (Vitamin B1) is an essential micronutrient and a cofactor for many central metabolic enzymes.
Targets&IC50	pancreatic:4.9 mM, Neuroblastoma:5.4 mM, Hypo19/7:12.5 µM
In vitro	METHODS: SK-N-BE cells (neuroblastoma cells) and Panc-1 cells (pancreatic cancer cells) were treated with Thiamine hydrochloride (10-5-102 mM) for 5 days, and the cell growth inhibition was detected by crystal violet assay. RESULTS: Thiamine hydrochloride inhibited the growth of SK-N-BE cells (IC50=4.9 mM) and Panc-1 cells (IC50=5.4 mM). [1]
In vivo	METHODS: To investigate the effect of Thiamine hydrochloride on memory, Thiamine hydrochloride (300 µg/kg) was administered to adult mice with scopolamine-induced memory dysfunction every other day for the last 14 days of the experiment. RESULTS: Thiamine hydrochloride improved memory dysfunction in mice through Nrf-2/TLR4 signaling pathway. [2] METHODS: To study the anti-inflammatory and anti-hyperalgesia effects of Thiamine hydrochloride, Thiamine hydrochloride (150-200 mg/kg) was administered intraperitoneally to Wistar rats with adjuvant-induced arthritis for 21 days. RESULTS: Thiamine hydrochloride showed anti-inflammatory and anti-hyperalgesia effects. [3] METHODS: To study the anti-inflammatory activity of Thiamine hydrochloride, Thiamine hydrochloride (20 mg/kg) was administered intraperitoneally to rats with colitis for 5 days. RESULTS: Thiamine hydrochloride attenuated macroscopic parameters and the summary colitis index in colitis rats. [4]
Synonyms	Vitamin B1 hydrochloride, Thiamine HCl, Thiamine chloride hydrochloride

Chemical Properties

Molecular Weight	337.27
Formula	C₁₂H₁₈Cl₂N₄OS
Cas No.	67-03-8
Smiles	Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=C(N)N=C(C)N=C1
Relative Density.	1.401 g/cm3

Storage & Solubility Information

Storage

keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 95 mg/mL (281.67 mM), Sonication is recommended.

DMSO: 3.37 mg/mL (9.99 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.9650 mL	14.8249 mL	29.6498 mL	148.2492 mL
5 mM	0.5930 mL	2.9650 mL	5.9300 mL	29.6498 mL

H2O

	1mg	5mg	10mg	50mg
10 mM	0.2965 mL	1.4825 mL	2.9650 mL	14.8249 mL
20 mM	0.1482 mL	0.7412 mL	1.4825 mL	7.4125 mL
50 mM	0.0593 mL	0.2965 mL	0.5930 mL	2.9650 mL
100 mM	0.0296 mL	0.1482 mL	0.2965 mL	1.4825 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc