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Thiamine hydrochloride
🥰Excellent
Catalog No. T0894Cas No. 67-03-8
Alias Vitamin B1 hydrochloride, Thiamine HCl, Thiamine chloride hydrochloride
Thiamine hydrochloride (Vitamin B1) is an essential micronutrient and a cofactor for many central metabolic enzymes.
Thiamine hydrochloride
🥰Excellent
Purity: 99.63%
Catalog No. T0894Alias Vitamin B1 hydrochloride, Thiamine HCl, Thiamine chloride hydrochlorideCas No. 67-03-8
Thiamine hydrochloride (Vitamin B1) is an essential micronutrient and a cofactor for many central metabolic enzymes.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 mg | $35 | In Stock | |
| 100 mg | $48 | In Stock | |
| 500 mg | $59 | In Stock | |
| 1 g | $65 | In Stock | |
| 2 g | $92 | In Stock |
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Purity:99.63%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Thiamine hydrochloride (Vitamin B1) is an essential micronutrient and a cofactor for many central metabolic enzymes. |
| Targets&IC50 | pancreatic:4.9 mM, Hypo19/7:12.5 µM, Neuroblastoma:5.4 mM |
| In vitro | METHODS: SK-N-BE cells (neuroblastoma cells) and Panc-1 cells (pancreatic cancer cells) were treated with Thiamine hydrochloride (10-5-102 mM) for 5 days, and the cell growth inhibition was detected by crystal violet assay. RESULTS: Thiamine hydrochloride inhibited the growth of SK-N-BE cells (IC50=4.9 mM) and Panc-1 cells (IC50=5.4 mM). [1] |
| In vivo | METHODS: To investigate the effect of Thiamine hydrochloride on memory, Thiamine hydrochloride (300 µg/kg) was administered to adult mice with scopolamine-induced memory dysfunction every other day for the last 14 days of the experiment. RESULTS: Thiamine hydrochloride improved memory dysfunction in mice through Nrf-2/TLR4 signaling pathway. [2] METHODS: To study the anti-inflammatory and anti-hyperalgesia effects of Thiamine hydrochloride, Thiamine hydrochloride (150-200 mg/kg) was administered intraperitoneally to Wistar rats with adjuvant-induced arthritis for 21 days. RESULTS: Thiamine hydrochloride showed anti-inflammatory and anti-hyperalgesia effects. [3] METHODS: To study the anti-inflammatory activity of Thiamine hydrochloride, Thiamine hydrochloride (20 mg/kg) was administered intraperitoneally to rats with colitis for 5 days. RESULTS: Thiamine hydrochloride attenuated macroscopic parameters and the summary colitis index in colitis rats. [4] |
| Synonyms | Vitamin B1 hydrochloride, Thiamine HCl, Thiamine chloride hydrochloride |
| Molecular Weight | 337.27 |
| Formula | C12H18Cl2N4OS |
| Cas No. | 67-03-8 |
| Smiles | Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=C(N)N=C(C)N=C1 |
| Relative Density. | 1.401 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 95 mg/mL (281.67 mM), Sonication is recommended.  DMSO: 3.37 mg/mL (10.01 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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