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BMS-470539 dihydrochloride

Name: BMS-470539 dihydrochloride
Brand: TargetMol
SKU: T10568
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: BMS470539 dihydrochloride, BMS 470539 dihydrochloride) Copy Product Info

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Synonyms: BMS470539 dihydrochloride, BMS 470539 dihydrochloride

Catalog No. T10568 Copy Product Info

Purity: 99.09%

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BMS-470539 dihydrochloride is a selective and highly potent melanocortin 1 receptor (MC-1 R) agonist with anti-inflammatory activity. BMS-470539 attenuates oxidative stress and neuronal apoptosis via the MC1R/cAMP/PKA/Nurr1 signaling pathway in a neonatal hypoxia-ischemia rat model.

Cas No. 2341796-82-3

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Pack Size	Price	USA Stock	Global Stock
1 mg	$52	In Stock	In Stock
5 mg	$123	In Stock	In Stock
10 mg	$198	In Stock	In Stock
25 mg	$455	In Stock	In Stock
50 mg	$745	In Stock	In Stock
100 mg	$1,180	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.09%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Information

Bioactivity

Description	BMS-470539 dihydrochloride is a selective and highly potent melanocortin 1 receptor (MC-1 R) agonist with anti-inflammatory activity. BMS-470539 attenuates oxidative stress and neuronal apoptosis via the MC1R/cAMP/PKA/Nurr1 signaling pathway in a neonatal hypoxia-ischemia rat model.
Targets & IC50	MC1R:120 nM, MC1R:28 nM (EC50)
In vitro	Method: BMS-470539 dihydrochloride (0-1μM, 15 minutes) was used to treat HBL cells stably transfected with NF-B luciferase reporter gene, and then treated with 0.5 ng/mL TNF-α for 4 hours to study its effect on stable transfection. Effects of NF-B luciferase reporter gene on TNF-α-stimulated luciferase activation in HBL cells. Result:BMS-470539 dihydrochloride treatment of HBL cells with NF-B luciferase reporter gene caused a dose-dependent significant reduction in TNF-α-stimulated NF-B luciferase activity. ^[2]
In vivo	Method: BMS-470539 dihydrochloride (2.05-18.47 mg/kg, intravenous injection, 125 minutes) was used to treat WT and MC1 receptor-negative e/e mice to study its effects on mesenteric microcirculation. Result:BMS-470539 dihydrochloride treatment of mice inhibited cell adhesion and migration, had no effect on cell rolling, and also inhibited the tissue expression of two chemokines, CXCL1 and CCL2. ^[3]
Synonyms	BMS470539 dihydrochloride, BMS 470539 dihydrochloride

Chemical Properties

Molecular Weight	632.62
Formula	C₃₂H₄₃Cl₂N₅O₄
Cas No.	2341796-82-3
Smiles	CCCC(C1(C2=CC=CC=C2)CCN(CC1)C([C@H](NC([C@@H](N)CC3=CN=CN3C)=O)CC4=CC=C(C=C4)OC)=O)=O.Cl.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Store at low temperature,Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (237.11 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 10 mg/mL (15.81 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5807 mL	7.9036 mL	15.8073 mL	79.0364 mL
5 mM	0.3161 mL	1.5807 mL	3.1615 mL	15.8073 mL
10 mM	0.1581 mL	0.7904 mL	1.5807 mL	7.9036 mL
20 mM	0.0790 mL	0.3952 mL	0.7904 mL	3.9518 mL
50 mM	0.0316 mL	0.1581 mL	0.3161 mL	1.5807 mL
100 mM	0.0158 mL	0.0790 mL	0.1581 mL	0.7904 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Product Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

MelanocortinReceptorMelanocortin-1 receptorMelanocortin ReceptorBMS-470539 DihydrochlorideBMS-470539BMS470539BMS 470539

Related Tags: BMS-470539 dihydrochloride chemical structure | BMS-470539 dihydrochloride in vivo | BMS-470539 dihydrochloride in vitro | BMS-470539 dihydrochloride formula | BMS-470539 dihydrochloride molecular weight