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Malabaricone B

Name: Malabaricone B
Brand: TargetMol
SKU: TN6771
Price: 67 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN6771Cas No. 63335-24-0

Malabaricone B is a Spice-derived phenolic, it induces mitochondrial damage in lung cancer cells via a p53-independent pathway.

Malabaricone B

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Purity: 99.91%

Catalog No. TN6771Cas No. 63335-24-0

Malabaricone B is a Spice-derived phenolic, it induces mitochondrial damage in lung cancer cells via a p53-independent pathway.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$67	In Stock	In Stock
2 mg	$97	In Stock	In Stock
5 mg	$162	In Stock	In Stock
10 mg	$243	In Stock	In Stock
25 mg	$412	In Stock	In Stock
50 mg	$588	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$168	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.91%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Malabaricone B AI Summary

Malabaricone B demonstrates broad-spectrum antimicrobial activity, exhibiting potent effects against several bacteria and fungi. It shows a low minimum inhibitory concentration (MIC) of 1.0 ug/mL against Staphylococcus aureus, Bacillus subtilis, and Streptococcus durans after 24 and 48 hours, although the MIC for Streptococcus durans increases to 2.0 ug/mL after 48 hours. For Candida albicans, the MIC ranges between 4.0 to 16.0 ug/mL after 24 and 48 hours. This compound also exhibits significant cytotoxic activity against human MCF7 cells, with an IC50 value of 6860.0 nM in a 72-hour MTT assay. Additionally, Malabaricone B shows moderate cholinesterase inhibitory activity with IC50 values of 1760.0 nM for butyrylcholinesterase (BChE) and 1840.0 nM for acetylcholinesterase (AChE), displaying a slight preference for AChE inhibition. At a concentration of 100 ug/ml, it substantially inhibits BChE (87.35% inhibition) and AChE (95.86% inhibition). Furthermore, this compound competitively inhibits Streptococcus pneumoniae sialidase enzymes NanA with an IC50 of 400.0 nM and a Ki of 500.0 nM. It also inhibits NanB and NanC noncompetitively, with respective IC50 values of 5700.0 nM and 14300.0 nM, and Ki values of 5600.0 nM and 5800.0 nM. Beyond its antimicrobial and cholinesterase inhibitory properties, Malabaricone B inhibits alpha-amylase and alpha-glucosidase enzymes, demonstrating potential antidiabetic activity by enhancing glucose uptake in rat L6 cells. It also inhibits the formation of advanced glycated end products, indicating antiglycation properties. Additionally, the compound exhibits inhibition of sphingomyelin synthase enzymes SMS1 and SMS2 with IC50 values of 3500.0 nM and 2500.0 nM, respectively, and shows noncompetitive inhibition with lower IC50 values of 2000.0 nM and 1000.0 nM when using a specific substrate, suggesting its utility as a modulator of sphingomyelin synthase activity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Malabaricone B is a Spice-derived phenolic, it induces mitochondrial damage in lung cancer cells via a p53-independent pathway.

Chemical Properties

Molecular Weight	342.43
Formula	C₂₁H₂₆O₄
Cas No.	63335-24-0
Smiles	Oc1ccc(CCCCCCCCC(=O)c2c(O)cccc2O)cc1
Relative Density.	1.17g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (175.22 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9203 mL	14.6015 mL	29.2030 mL	146.0152 mL
5 mM	0.5841 mL	2.9203 mL	5.8406 mL	29.2030 mL
10 mM	0.2920 mL	1.4602 mL	2.9203 mL	14.6015 mL
20 mM	0.1460 mL	0.7301 mL	1.4602 mL	7.3008 mL
50 mM	0.0584 mL	0.2920 mL	0.5841 mL	2.9203 mL
100 mM	0.0292 mL	0.1460 mL	0.2920 mL	1.4602 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc