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PAz-PC

Name: PAz-PC
Brand: TargetMol
SKU: T35956
Rating: 4.5 (1 reviews)

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Catalog No. T35956Cas No. 117746-89-1

Alias PAzePC, Azelaoyl PC, 1-Palmitoyl-2-Azelaoyl PC

PAz-PC (Azelaoyl PC) is a truncated phospholipid oxidation product that enhances endothelial barrier disruption induced by heat-inactivated Staphylococcus aureus (HKSA).

PAz-PC

😃Good

Catalog No. T35956Alias PAzePC, Azelaoyl PC, 1-Palmitoyl-2-Azelaoyl PCCas No. 117746-89-1

PAz-PC (Azelaoyl PC) is a truncated phospholipid oxidation product that enhances endothelial barrier disruption induced by heat-inactivated Staphylococcus aureus (HKSA).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$142	35 days	35 days
5 mg	$663	35 days	35 days
10 mg	$1,130	35 days	35 days
25 mg	$2,530	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Appearance:Liquid

Color:Transparent

Resource Download

COA

Product Introduction

Bioactivity

Description	PAz-PC (Azelaoyl PC) is a truncated phospholipid oxidation product that enhances endothelial barrier disruption induced by heat-inactivated Staphylococcus aureus (HKSA).
In vitro	PAz-PC can cause acute lung endothelial cell barrier breakdown. [1] The oxidation of phospholipid PAz-PC can promote the permeability of Bax to mitochondrial membrane. [2]
Synonyms	PAzePC, Azelaoyl PC, 1-Palmitoyl-2-Azelaoyl PC

Chemical Properties

Molecular Weight	665.84
Formula	C₃₃H₆₄NO₁₀P
Cas No.	117746-89-1
Smiles	[C@H](COP(OCC[N+](C)(C)C)(=O)[O-])(COC(CCCCCCCCCCCCCCC)=O)OC(CCCCCCCC(O)=O)=O
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

PBS (pH 7.2): 1 mg/mL (1.5 mM), Sonication is recommended.

DMF: 1 mg/mL (1.5 mM), Sonication is recommended.

DMSO: 1 mg/mL (1.5 mM), Sonication is recommended.

Ethanol: 8 mg/mL (12.01 mM), Sonication is recommended.

Solution Preparation Table

PBS (pH 7.2)/DMF/DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	1.5019 mL	7.5093 mL	15.0186 mL	75.0931 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc