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AZD3988

Name: AZD3988
Brand: TargetMol
SKU: T14375
Price: 49 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14375Cas No. 892489-52-0

AZD3988 is an orally active and highly potent inhibitor of diacylglycerol acyltransferase-1 (DGAT-1) for the study of diabetes and obesity.

AZD3988

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Purity: 99.32%

Catalog No. T14375Cas No. 892489-52-0

AZD3988 is an orally active and highly potent inhibitor of diacylglycerol acyltransferase-1 (DGAT-1) for the study of diabetes and obesity.

Pack Size	Price	Availability
1 mg	$49	In Stock
2 mg	$68	In Stock
5 mg	$123	In Stock
10 mg	$197	In Stock
25 mg	$343	In Stock
50 mg	$497	In Stock
1 mL x 10 mM (in DMSO)	$123	In Stock

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Purity:99.32%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	AZD3988 is an orally active and highly potent inhibitor of diacylglycerol acyltransferase-1 (DGAT-1) for the study of diabetes and obesity.
Targets&IC50	DGAT-1 (mouse):11 nM, DGAT-1 (human):6 nM, DGAT-1 (human):6 nM, DGAT-1 (rat):5 nM
In vitro	In mice, rats, and dogs, AZD3988 (0.5, 1, 2, 5 mg/kg; intravenous injection) exhibited good bioavailability[1].

Chemical Properties

Molecular Weight	456.44
Formula	C₂₃H₂₂F₂N₄O₄
Cas No.	892489-52-0
Smiles	OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(NC(=O)c2nnc(Nc3ccc(F)c(F)c3)o2)cc1
Relative Density.	1.402
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (21.91 mM), Sonification is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1909 mL	10.9543 mL	21.9087 mL	109.5434 mL
5 mM	0.4382 mL	2.1909 mL	4.3817 mL	21.9087 mL
10 mM	0.2191 mL	1.0954 mL	2.1909 mL	10.9543 mL
20 mM	0.1095 mL	0.5477 mL	1.0954 mL	5.4772 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc