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Golotimod

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Catalog No. T11449LCas No. 229305-39-9
Alias SCV 07, Gamma-D-glutamyl-L-tryptophan

Golotimod (SCV 07) is an antimicrobial dipeptide with immunomodulatory activity that significantly improves the efficacy of anti-tuberculosis therapy, induces thymic and splenic cell proliferation, modulates macrophage function, and inhibits STAT3 signaling.Golotimod has been used in the study of recurrent genital Herpes Simplex Virus 2 (HSV-2) infection and oral mucositis.

Golotimod
Other Forms of Golotimod:

Golotimod

🥰Excellent
Purity: 99.98%
Catalog No. T11449LAlias SCV 07, Gamma-D-glutamyl-L-tryptophanCas No. 229305-39-9
Golotimod (SCV 07) is an antimicrobial dipeptide with immunomodulatory activity that significantly improves the efficacy of anti-tuberculosis therapy, induces thymic and splenic cell proliferation, modulates macrophage function, and inhibits STAT3 signaling.Golotimod has been used in the study of recurrent genital Herpes Simplex Virus 2 (HSV-2) infection and oral mucositis.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$33In StockIn Stock
5 mg$52In StockIn Stock
10 mg$81In StockIn Stock
25 mg$137In StockIn Stock
50 mg$198In StockIn Stock
100 mg$289-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.98%
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COA HPLC MS HNMR

Product Introduction

Bioactivity
Description
Golotimod (SCV 07) is an antimicrobial dipeptide with immunomodulatory activity that significantly improves the efficacy of anti-tuberculosis therapy, induces thymic and splenic cell proliferation, modulates macrophage function, and inhibits STAT3 signaling.Golotimod has been used in the study of recurrent genital Herpes Simplex Virus 2 (HSV-2) infection and oral mucositis.
In vivo
In female Hartley guinea pigs (250-300 g) infected with HSV-2, Golotimod (100 μg/kg; oral gavage or subcutaneous injection; 5 days) reduced the incidence of lesions from 55% (one week before treatment) to only 18% by oral administration[1].
SynonymsSCV 07, Gamma-D-glutamyl-L-tryptophan
Chemical Properties
Molecular Weight333.34
FormulaC16H19N3O5
Cas No.229305-39-9
Smiles[H][C@@](N)(CCC(=O)N[C@@]([H])(Cc1c[nH]c2ccccc12)C(O)=O)C(O)=O
Relative Density.1.428g/cm3
SequenceH-D-gGlu-Trp-OH
Sequence ShortXW
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 100 mg/mL (300.00 mM), Sonification is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM2.9999 mL14.9997 mL29.9994 mL149.9970 mL
5 mM0.6000 mL2.9999 mL5.9999 mL29.9994 mL
10 mM0.3000 mL1.5000 mL2.9999 mL14.9997 mL
20 mM0.1500 mL0.7500 mL1.5000 mL7.4999 mL
50 mM0.0600 mL0.3000 mL0.6000 mL2.9999 mL
100 mM0.0300 mL0.1500 mL0.3000 mL1.5000 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

STAT3SCV-07SCV07GolotimodAntibiotic
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