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Golotimod

Name: Golotimod
Brand: TargetMol
SKU: T11449L
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11449LCas No. 229305-39-9

Alias SCV 07, Gamma-D-glutamyl-L-tryptophan

Golotimod (SCV 07) is an antimicrobial dipeptide with immunomodulatory activity that significantly improves the efficacy of anti-tuberculosis therapy, induces thymic and splenic cell proliferation, modulates macrophage function, and inhibits STAT3 signaling.Golotimod has been used in the study of recurrent genital Herpes Simplex Virus 2 (HSV-2) infection and oral mucositis.

Golotimod

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Purity: 99.98%

Catalog No. T11449LAlias SCV 07, Gamma-D-glutamyl-L-tryptophanCas No. 229305-39-9

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$33	In Stock	In Stock
5 mg	$52	In Stock	In Stock
10 mg	$81	In Stock	In Stock
25 mg	$137	In Stock	In Stock
50 mg	$198	In Stock	In Stock
100 mg	$289	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.98%

Appearance:Solid

Color:White

Resource Download

COA HPLC MS HNMR

Product Introduction

Bioactivity

Description	Golotimod (SCV 07) is an antimicrobial dipeptide with immunomodulatory activity that significantly improves the efficacy of anti-tuberculosis therapy, induces thymic and splenic cell proliferation, modulates macrophage function, and inhibits STAT3 signaling.Golotimod has been used in the study of recurrent genital Herpes Simplex Virus 2 (HSV-2) infection and oral mucositis.
In vivo	In female Hartley guinea pigs (250-300 g) infected with HSV-2, Golotimod (100 μg/kg; oral gavage or subcutaneous injection; 5 days) reduced the incidence of lesions from 55% (one week before treatment) to only 18% by oral administration[1].
Synonyms	SCV 07, Gamma-D-glutamyl-L-tryptophan

Chemical Properties

Molecular Weight	333.34
Formula	C₁₆H₁₉N₃O₅
Cas No.	229305-39-9
Smiles	[H][C@@](N)(CCC(=O)N[C@@]([H])(Cc1c[nH]c2ccccc12)C(O)=O)C(O)=O
Relative Density.	1.428g/cm3
Sequence	H-D-gGlu-Trp-OH
Sequence Short	XW

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 100 mg/mL (299.99 mM), Sonification is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.9999 mL	14.9997 mL	29.9994 mL	149.9970 mL
5 mM	0.6000 mL	2.9999 mL	5.9999 mL	29.9994 mL
10 mM	0.3000 mL	1.5000 mL	2.9999 mL	14.9997 mL
20 mM	0.1500 mL	0.7500 mL	1.5000 mL	7.4999 mL
50 mM	0.0600 mL	0.3000 mL	0.6000 mL	2.9999 mL
100 mM	0.0300 mL	0.1500 mL	0.3000 mL	1.5000 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc