Contact UsQuotation
Shopping Cart
Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPBioactivityChemical infoStorage&SolubilityCalculator

MY-1B

😃Good
Catalog No. T85335Cas No. 2929308-79-0
Alias MY1B

MY-1B is a nitrogen-containing substituted butenamide stereoprobe, capable of blocking stereoselective enrichment of NSUN2, specifically binding to NSUN2 at C271.

MY-1B

MY-1B

😃Good
Purity: 99.81%
Catalog No. T85335Alias MY1BCas No. 2929308-79-0
MY-1B is a nitrogen-containing substituted butenamide stereoprobe, capable of blocking stereoselective enrichment of NSUN2, specifically binding to NSUN2 at C271.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$136In StockIn Stock
5 mg$338In StockIn Stock
10 mg$538In StockIn Stock
25 mg$1,080In StockIn Stock
50 mg$1,490In StockIn Stock
100 mg$1,980In Stock-
200 mg$2,6704-6 weeks4-6 weeks
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
TargetMol
View More

Batch Information

Select Batch
Purity:99.81%
ee:100%
Contact us for more batch information

Resource Download

COA CSFC HNMR LCMS ORP

Product Introduction

Bioactivity
Description
MY-1B is a nitrogen-containing substituted butenamide stereoprobe, capable of blocking stereoselective enrichment of NSUN2, specifically binding to NSUN2 at C271.
Targets&IC50
NSUN2 methyltransferase:67 ± 15 M (Kinact/Ki), NSUN2:1.3 μM, NSUN2:2.4 µM (RNA methylation assays)
In vitro
Methods: The binding of NSUN2_C271 was observed in the human prostate cancer cell line 22Rv1 treated with 5 or 20 μM MY-1B (3 hours).
Results: Almost complete binding of NSUN2_C271 (>90%) was observed in the human prostate cancer cell line 22Rv1. [1]
The Kinact/Ki value of MY-1B (2.5-20 µM) against recombinant NSUN2 methyltransferase activity at different pre-incubation times and concentrations was 67±15 M. [1]
SynonymsMY1B
Chemical Properties
Molecular Weight436.3
FormulaC22H18BrN3O2
Cas No.2929308-79-0
SmilesC(NC=1C2=C(C=CC1)C=CC=N2)(=O)[C@H]3[C@H](CN3C(C=C)=O)C4=CC=C(Br)C=C4
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80.00 mg/mL (183.36 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.56 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2920 mL11.4600 mL22.9200 mL114.6000 mL
5 mM0.4584 mL2.2920 mL4.5840 mL22.9200 mL
10 mM0.2292 mL1.1460 mL2.2920 mL11.4600 mL
20 mM0.1146 mL0.5730 mL1.1460 mL5.7300 mL
50 mM0.0458 mL0.2292 mL0.4584 mL2.2920 mL
100 mM0.0229 mL0.1146 mL0.2292 mL1.1460 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Related Tags: buy MY-1B | purchase MY-1B | MY-1B cost | order MY-1B | MY-1B chemical structure | MY-1B in vitro | MY-1B formula | MY-1B molecular weight
TargetMol | Logo

Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.