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Angiotensinogen (1-14), human
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Catalog No. TP1842Cas No. 104180-23-6
Angiotensinogen (1-14), human, also known as angiotensin precursor, is a serum globulin synthesized by the liver that is hydrolyzed by renin to form angiotensin I,
Angiotensinogen (1-14), human
Copy Product Info😃Good
Catalog No. TP1842Cas No. 104180-23-6
Angiotensinogen (1-14), human, also known as angiotensin precursor, is a serum globulin synthesized by the liver that is hydrolyzed by renin to form angiotensin I,
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $72 | - | In Stock | |
| 5 mg | $297 | Inquiry | Inquiry | |
| 10 mg | $418 | Inquiry | Inquiry |
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| Description | Angiotensinogen (1-14), human, also known as angiotensin precursor, is a serum globulin synthesized by the liver that is hydrolyzed by renin to form angiotensin I, |
| In vitro | Angiotensinogen (1-14), human (AGT), the common precursor of the angiotensin peptide family, consists of 485 amino acids in humans, with the N-terminal 33 amino acids serving as a signal peptide. Renin specifically cleaves amino acids 34-43 (the 10th residue after the signal peptide is removed) to release angiotensin I (AngI), which then generates a variety of bioactive peptides through a cascade reaction. Notably, this enzymatic cleavage mechanism is conserved across species—most mammalian AGTs can be recognized and cleaved by human renin, and synthetic peptides containing only the N-terminal sequence can mimic the function of the natural substrate. This property suggests that the N-terminal domain of AGT plays a crucial role in renin recognition. [1-2] |
| Molecular Weight | 1760.01 |
| Formula | C83H122N24O19 |
| Cas No. | 104180-23-6 |
| Smiles | C([C@H](CC1=CN=CN1)NC([C@@H](NC([C@H](CC2=CC=C(O)C=C2)NC([C@@H](NC([C@@H](NC([C@H](CC(O)=O)N)=O)CCCNC(=N)N)=O)C(C)C)=O)=O)[C@H](CC)C)=O)(=O)N3[C@H](C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CC5=CN=CN5)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC6=CN=CN6)C(N[C@@H](CC(N)=O)C(O)=O)=O)=O)[C@H](CC)C)=O)[C@H](C)C)=O)CC(C)C)=O)=O)=O)CCC3 |
| Relative Density. | no data available |
| Sequence | Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn |
| Sequence Short | DRVYIHPFHLVIHN |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O: ≥ 4.8 mg/mL, Sonication is recommended. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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