Shopping Cart
Remove All
Your shopping cart is currently empty
ALV1
Copy Product Info
😃Good
Catalog No. T63339Cas No. 2438124-79-7
ALV1 is a molecular glue degrader that targets and degrades Ikaros (IKZF1) and Helios (IKZF2), with DC50 values of 2.5 nM and 10.3 nM, respectively. ALV1 binds to CRBN with an IC50 of 0.55 μM and induces the dimerization of CRBN and Helios. It can be used to investigate the properties and functions of regulatory T cells .
ALV1
Copy Product Info😃Good
Purity: 99.86%
Catalog No. T63339Cas No. 2438124-79-7
ALV1 is a molecular glue degrader that targets and degrades Ikaros (IKZF1) and Helios (IKZF2), with DC50 values of 2.5 nM and 10.3 nM, respectively. ALV1 binds to CRBN with an IC50 of 0.55 μM and induces the dimerization of CRBN and Helios. It can be used to investigate the properties and functions of regulatory T cells .
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $113 | - | In Stock | |
| 5 mg | $289 | - | In Stock | |
| 10 mg | $463 | - | In Stock | |
| 25 mg | $953 | - | In Stock | |
| 50 mg | $1,280 | - | In Stock | |
| 100 mg | $1,730 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $318 | - | In Stock |
Add to Cart
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
Select Batch
Purity:99.86%
Appearance:Solid
Color:Yellow
Contact us for more batch information
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ALV1 is a molecular glue degrader that targets and degrades Ikaros (IKZF1) and Helios (IKZF2), with DC50 values of 2.5 nM and 10.3 nM, respectively. ALV1 binds to CRBN with an IC50 of 0.55 μM and induces the dimerization of CRBN and Helios. It can be used to investigate the properties and functions of regulatory T cells . |
| Targets&IC50 | CRBN:0.55 μM, IKZF2:10.3 nM (DC₅₀), IKZF1:2.5 nM (DC₅₀) |
| In vitro | ALV1 (0–10 μM, 4–18 hours) induces degradation of Ikaros and Helios and promotes IL‑2 secretion in Jurkat cells [1]. ALV1 (1 μM, 24 hours) effectively degrades Ikaros and Helios in Treg cells isolated from human peripheral blood [1]. ALV1 (0.1–10 μM, 4 hours) induces degradation of Ikaros and Helios without affecting the stability of GSPT1 in Jurkat cells [1]. ALV1 (1 μM, 4 hours) induces Helios degradation with no detectable off‑target effects in Jurkat cells [1]. ALV1 (1 μM, 18 hours) promotes IL‑2 secretion more strongly than lenalidomide in Jurkat cells, suggesting that Helios exerts a stronger inhibitory effect on IL‑2 production in this system [1]. |
| Molecular Weight | 494.93 |
| Formula | C25H23ClN4O5 |
| Cas No. | 2438124-79-7 |
| Smiles | O=C1C=C(NC2=CC=CC(=C2)CCC(=O)NC3=CC=C(C(Cl)=C3)C)C(=O)N1C4C(=O)NC(=O)CC4 |
| Storage | store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (80.82 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
| |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy ALV1 | purchase ALV1 | ALV1 cost | order ALV1 | ALV1 chemical structure | ALV1 in vitro | ALV1 formula | ALV1 molecular weight
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.