Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ALV1 is a potent degradation agent of Ikaros and Helios, with similar degradation activity against IKZF1/2/3. ALV1 significantly reduced the protein abundance of IKZF1-4, CK1α (casein kinase 1α, CSNK1A1) and ribosomal protein RPL4, and induced Helios/CRBN dimerization, which promoted IL-2 secretion.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,050.00 | |
50 mg | 6-8 weeks | $ 1,364.00 | |
100 mg | 6-8 weeks | $ 1,996.00 |
Description | ALV1 is a potent degradation agent of Ikaros and Helios, with similar degradation activity against IKZF1/2/3. ALV1 significantly reduced the protein abundance of IKZF1-4, CK1α (casein kinase 1α, CSNK1A1) and ribosomal protein RPL4, and induced Helios/CRBN dimerization, which promoted IL-2 secretion. |
Molecular Weight | 494.93 |
Formula | C25H23ClN4O5 |
CAS No. | 2438124-79-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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ALV1 2438124-79-7 inhibitor inhibit