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MDK-6983

Name: MDK-6983
Brand: TargetMol
SKU: T28001
Price: 1110 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28001Cas No. 1227476-98-3

Alias MDK-6983, MDK6983, Compound 6k, Autophagy inhibitor 6k

MDK-6983 (MDK-6983) is an inhibitor of autophagy and disrupts the dynamics of actin cytoskeleton in human melanoma cells.

MDK-6983

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Purity: 99.68%

Catalog No. T28001Alias MDK-6983, MDK6983, Compound 6k, Autophagy inhibitor 6kCas No. 1227476-98-3

MDK-6983 (MDK-6983) is an inhibitor of autophagy and disrupts the dynamics of actin cytoskeleton in human melanoma cells.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$117	In Stock	In Stock
5 mg	$262	In Stock	In Stock
10 mg	$387	In Stock	In Stock
25 mg	$592	In Stock	In Stock
50 mg	$828	In Stock	In Stock
100 mg	$1,110	In Stock	In Stock
500 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$298	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.68%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

MDK-6983 AI Summary

MDK-6983 induces apoptosis in human G361 cells by activating caspase-3/7 at a concentration of 2 µM after 24 hours. It exhibits cytotoxic effects against multiple human cell lines, such as HOS, HCT116, HeLa, G361, MCF7, and K562, with IC50 values spanning from 1100 nM to 3500 nM after 72 hours..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	MDK-6983 (MDK-6983) is an inhibitor of autophagy and disrupts the dynamics of actin cytoskeleton in human melanoma cells.
Synonyms	MDK-6983, MDK6983, Compound 6k, Autophagy inhibitor 6k

Chemical Properties

Molecular Weight	429.3
Formula	C₂₂H₁₈Cl₂N₂O₃
Cas No.	1227476-98-3
Smiles	[C@H](CC1=CC=CC=C1)(NC(=O)C2=C(O)C=CC(Cl)=C2)C(NC3=CC=C(Cl)C=C3)=O
Relative Density.	1.397 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (104.82 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3294 mL	11.6469 mL	23.2937 mL	116.4687 mL
5 mM	0.4659 mL	2.3294 mL	4.6587 mL	23.2937 mL
10 mM	0.2329 mL	1.1647 mL	2.3294 mL	11.6469 mL
20 mM	0.1165 mL	0.5823 mL	1.1647 mL	5.8234 mL
50 mM	0.0466 mL	0.2329 mL	0.4659 mL	2.3294 mL
100 mM	0.0233 mL	0.1165 mL	0.2329 mL	1.1647 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc