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Navafenterol saccharinate
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Catalog No. T30265Cas No. 1648550-37-1
Alias LAS-191351 saccharinate, LAS191351 saccharinate, AZD-8871 saccharinate, AZD8871 saccharinate
Navafenterol saccharinate (AZD-887 saccharinate) is an inhaled, dual-acting, potent, selective, and long-lasting M3-antagonist/β2-agonist that demonstrates high affinity for the human M3 receptor with a pIC50 of 9.5 and strong β2-adrenoceptor agonism with a pEC50 of 9.5. Navafenterol provides a sustained bronchoprotective and antisialagogue effects with a favorable cardiovascular safety profile, and serving as a valuable investigational compound for chronic obstructive pulmonary disease research.
Navafenterol saccharinate
😃Good
Purity: 98.67%
Catalog No. T30265Alias LAS-191351 saccharinate, LAS191351 saccharinate, AZD-8871 saccharinate, AZD8871 saccharinateCas No. 1648550-37-1
Navafenterol saccharinate (AZD-887 saccharinate) is an inhaled, dual-acting, potent, selective, and long-lasting M3-antagonist/β2-agonist that demonstrates high affinity for the human M3 receptor with a pIC50 of 9.5 and strong β2-adrenoceptor agonism with a pEC50 of 9.5. Navafenterol provides a sustained bronchoprotective and antisialagogue effects with a favorable cardiovascular safety profile, and serving as a valuable investigational compound for chronic obstructive pulmonary disease research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $293 | - | In Stock | |
| 5 mg | $722 | - | In Stock | |
| 10 mg | $987 | - | In Stock | |
| 25 mg | $1,520 | - | In Stock | |
| 50 mg | $1,980 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.67%
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Navafenterol saccharinate (AZD-887 saccharinate) is an inhaled, dual-acting, potent, selective, and long-lasting M3-antagonist/β2-agonist that demonstrates high affinity for the human M3 receptor with a pIC50 of 9.5 and strong β2-adrenoceptor agonism with a pEC50 of 9.5. Navafenterol provides a sustained bronchoprotective and antisialagogue effects with a favorable cardiovascular safety profile, and serving as a valuable investigational compound for chronic obstructive pulmonary disease research. |
| In vitro | In binding and functional assays, Navafenterol saccharinate acted as a human M3 receptor antagonist (pIC50 9.5) and β2-adrenoceptor agonist (pEC50 9.5) [1]. |
| In vivo | In preclinical models using guinea pigs and Beagle dogs, inhaled Navafenterol saccharinate prevents acetylcholine-induced bronchoconstriction. In dogs, a dosage of 10 ug/kg resulted in a bronchoprotective half-life exceeding 24 hours. The estimated IC50 for antisialagogue activity (138.4 ug/mL) was higher than the IC50 for bronchoconstriction inhibition (2.1 ug/mL). At doses providing bronchoprotection, minimal effects on heart rate or salivation were observed in these models [2]. |
| Synonyms | LAS-191351 saccharinate, LAS191351 saccharinate, AZD-8871 saccharinate, AZD8871 saccharinate |
| Molecular Weight | 926.09 |
| Formula | C45H47N7O9S3 |
| Cas No. | 1648550-37-1 |
| Smiles | O=S1(=O)C=2C(C(=O)N1)=CC=CC2.C(C(O[C@H]1CC[C@H](N(CCCN2C=3C(N=N2)=CC(CNC[C@H](O)C4=C5C(=C(O)C=C4)NC(=O)C=C5)=CC3)C)CC1)=O)(O)(C6=CC=CS6)C7=CC=CS7 |
| Relative Density. | no data available |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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