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Sirpiglenastat

Name: Sirpiglenastat
Brand: TargetMol
SKU: T62560
Price: 313 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T62560Cas No. 2079939-05-0

Alias DRP-104

Sirpiglenastat (DRP-104), a glutamine antagonist and prodrug of DON, exhibits antitumor activity by inhibiting glutamine metabolism and stimulating both the innate and adaptive immune systems.

Sirpiglenastat

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Purity: 98.37%

Catalog No. T62560Alias DRP-104Cas No. 2079939-05-0

Sirpiglenastat (DRP-104), a glutamine antagonist and prodrug of DON, exhibits antitumor activity by inhibiting glutamine metabolism and stimulating both the innate and adaptive immune systems.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$313	In Stock	In Stock
5 mg	$943	In Stock	In Stock
10 mg	$1,270	In Stock	In Stock
25 mg	$1,880	In Stock	In Stock
50 mg	$2,530	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$917	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.37%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Sirpiglenastat (DRP-104), a glutamine antagonist and prodrug of DON, exhibits antitumor activity by inhibiting glutamine metabolism and stimulating both the innate and adaptive immune systems.
In vitro	Treatment with Sirpiglenastat (DRP-104) exhibits broad immune cell modulation effects, including an increase in T cells, NK cells, and macrophages. Sirpiglenastat also reduces the levels of pro-tumorigenic cytokines such as VEGF and KC (IL-8)[1].
In vivo	In CT26 bearing mice, treatment with Sirpiglenastat (DRP-104) at a dose of 0.5 mg/kg through subcutaneous injection once a day for 5 days results in a 90% inhibition of tumor growth by day 12, with a median survival of 36 days[1].Additionally, Sirpiglenastat treatment (0.5 mg/kg; s.c) significantly inhibits tumor growth in the H22 model[1].
Synonyms	DRP-104

Chemical Properties

Molecular Weight	441.48
Formula	C₂₂H₂₇N₅O₅
Cas No.	2079939-05-0
Smiles	C([C@@H](C(N[C@H](C(OC(C)C)=O)CCC(C=[N+]=[N-])=O)=O)NC(C)=O)C=1C=2C(NC1)=CC=CC2

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90.5 mg/mL (204.99 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2651 mL	11.3255 mL	22.6511 mL	113.2554 mL
5 mM	0.4530 mL	2.2651 mL	4.5302 mL	22.6511 mL
10 mM	0.2265 mL	1.1326 mL	2.2651 mL	11.3255 mL
20 mM	0.1133 mL	0.5663 mL	1.1326 mL	5.6628 mL
50 mM	0.0453 mL	0.2265 mL	0.4530 mL	2.2651 mL
100 mM	0.0227 mL	0.1133 mL	0.2265 mL	1.1326 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc