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Sirpiglenastat

Name: Sirpiglenastat
Brand: TargetMol
SKU: T62560
Price: 313 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T62560Cas No. 2079939-05-0

Alias DRP-104

Sirpiglenastat (DRP-104), a glutamine antagonist and prodrug of DON, exhibits antitumor activity by inhibiting glutamine metabolism and stimulating both the innate and adaptive immune systems.

Sirpiglenastat

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Purity: 98.37%

Catalog No. T62560Alias DRP-104Cas No. 2079939-05-0

Sirpiglenastat (DRP-104), a glutamine antagonist and prodrug of DON, exhibits antitumor activity by inhibiting glutamine metabolism and stimulating both the innate and adaptive immune systems.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$313	In Stock	In Stock
5 mg	$943	In Stock	In Stock
10 mg	$1,270	In Stock	In Stock
25 mg	$1,880	In Stock	In Stock
50 mg	$2,530	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$917	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:98.37%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Sirpiglenastat (DRP-104), a glutamine antagonist and prodrug of DON, exhibits antitumor activity by inhibiting glutamine metabolism and stimulating both the innate and adaptive immune systems.
In vitro	Treatment with Sirpiglenastat (DRP-104) exhibits broad immune cell modulation effects, including an increase in T cells, NK cells, and macrophages. Sirpiglenastat also reduces the levels of pro-tumorigenic cytokines such as VEGF and KC (IL-8)[1].
In vivo	In CT26 bearing mice, treatment with Sirpiglenastat (DRP-104) at a dose of 0.5 mg/kg through subcutaneous injection once a day for 5 days results in a 90% inhibition of tumor growth by day 12, with a median survival of 36 days[1].Additionally, Sirpiglenastat treatment (0.5 mg/kg; s.c) significantly inhibits tumor growth in the H22 model[1].
Synonyms	DRP-104

Chemical Properties

Molecular Weight	441.48
Formula	C₂₂H₂₇N₅O₅
Cas No.	2079939-05-0
Smiles	C([C@@H](C(N[C@H](C(OC(C)C)=O)CCC(C=[N+]=[N-])=O)=O)NC(C)=O)C=1C=2C(NC1)=CC=CC2

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90.5 mg/mL (204.99 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2651 mL	11.3255 mL	22.6511 mL	113.2554 mL
5 mM	0.4530 mL	2.2651 mL	4.5302 mL	22.6511 mL
10 mM	0.2265 mL	1.1326 mL	2.2651 mL	11.3255 mL
20 mM	0.1133 mL	0.5663 mL	1.1326 mL	5.6628 mL
50 mM	0.0453 mL	0.2265 mL	0.4530 mL	2.2651 mL
100 mM	0.0227 mL	0.1133 mL	0.2265 mL	1.1326 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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