SIRP beta 2 Protein, Human, Recombinant (hFc)

Name: SIRP beta 2 Protein, Human, Recombinant (hFc)
Brand: TargetMol
SKU: TMPJ-01160
Rating: 4.5 (1 reviews)

(Synonyms: SIRP-β-2, SIRPG, SIRP-beta-2, SIRP β2, SIRP beta 2, Signal-Regulatory Protein β-2, Signal-Regulatory Protein β2, Signal-Regulatory Protein Beta-2, Signal-Regulatory Protein Beta 2, PTPNS1L3, PTPN1L, dJ776F14.2) Copy Product Info

Synonyms: SIRP-β-2, SIRPG, SIRP-beta-2, SIRP β2, SIRP beta 2, Signal-Regulatory Protein β-2, Signal-Regulatory Protein β2, Signal-Regulatory Protein Beta-2, Signal-Regulatory Protein Beta 2, PTPNS1L3, PTPN1L, dJ776F14.2

Catalog No. TMPJ-01160 Copy Product Info

Signal-regulatory protein beta-2(SIRP-beta-2), is a monomeric single pass type I membrane glycoprotein, belongs to the SIRP/SHPS (CD172) family of the immunoglobulin (Ig) superfamily. The SIRP family are paired receptors that have similar extracellular domains but differing C-terminal domains and functions. A positively charged residue within the transmembrane domain, in analogy to SIRP-beta-1, is implicated to mediate interaction with the adaptor DAP12 protein, which contains immunoreceptor tyrosine-based activation motifs (ITAMs) . Proteins in the SIRP family are typically expressed in immune cells, especially in the myeloid lineages . Based on expression patterns, SIRPs are thought to have roles in immune regulation. SIRP family members role in innate immunity and host defense has potential significance as a therapeutic target in cancer and inflammation. There are currently no known mouse or rat homologs for this protein.

SIRP beta 2 Protein, Human, Recombinant (hFc)

Pack Size	Price	USA Stock	Global Stock
5 µg	$39	35 days	35 days
10 µg	$60	35 days	35 days
20 µg	$96	35 days	35 days
50 µg	$183	35 days	35 days
100 µg	$332	35 days	35 days
200 µg	$592	35 days	35 days
500 µg	$1,350	35 days	35 days
1 mg	$2,010	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	Signal-regulatory protein beta-2(SIRP-beta-2), is a monomeric single pass type I membrane glycoprotein, belongs to the SIRP/SHPS (CD172) family of the immunoglobulin (Ig) superfamily. The SIRP family are paired receptors that have similar extracellular domains but differing C-terminal domains and functions. A positively charged residue within the transmembrane domain, in analogy to SIRP-beta-1, is implicated to mediate interaction with the adaptor DAP12 protein, which contains immunoreceptor tyrosine-based activation motifs (ITAMs) . Proteins in the SIRP family are typically expressed in immune cells, especially in the myeloid lineages . Based on expression patterns, SIRPs are thought to have roles in immune regulation. SIRP family members role in innate immunity and host defense has potential significance as a therapeutic target in cancer and inflammation. There are currently no known mouse or rat homologs for this protein.
Species	Human
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	Q5JXA9
Amino Acid	Gln33-Gly287
Construction	Gln33-Gly287
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	SIRP-β-2, SIRPG, SIRP-beta-2, SIRP β2, SIRP beta 2, Signal-Regulatory Protein β-2, Signal-Regulatory Protein β2, Signal-Regulatory Protein Beta-2, Signal-Regulatory Protein Beta 2, PTPNS1L3, PTPN1L, dJ776F14.2
Research Background	Signal-regulatory protein beta-2(SIRP-beta-2), is a monomeric single pass type I membrane glycoprotein, belongs to the SIRP/SHPS (CD172) family of the immunoglobulin (Ig) superfamily. The SIRP family are paired receptors that have similar extracellular domains but differing C-terminal domains and functions. A positively charged residue within the transmembrane domain, in analogy to SIRP-beta-1, is implicated to mediate interaction with the adaptor DAP12 protein, which contains immunoreceptor tyrosine-based activation motifs (ITAMs) . Proteins in the SIRP family are typically expressed in immune cells, especially in the myeloid lineages . Based on expression patterns, SIRPs are thought to have roles in immune regulation. SIRP family members role in innate immunity and host defense has potential significance as a therapeutic target in cancer and inflammation. There are currently no known mouse or rat homologs for this protein.

Chemical Properties

Molecular Weight

80-95 KDa (reducing condition)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.