SIRP beta 2 Protein, Human, Recombinant (hFc)

Name: SIRP beta 2 Protein, Human, Recombinant (hFc)
Brand: TargetMol
SKU: TMPJ-01160
Rating: 4.5 (1 reviews)

(Synonyms: SIRP-β-2, SIRPG, SIRP-beta-2, SIRP β2, SIRP beta 2, Signal-Regulatory Protein β-2, Signal-Regulatory Protein β2, Signal-Regulatory Protein Beta-2, Signal-Regulatory Protein Beta 2, PTPNS1L3, PTPN1L, dJ776F14.2) Copy Product Info

Synonyms: SIRP-β-2, SIRPG, SIRP-beta-2, SIRP β2, SIRP beta 2, Signal-Regulatory Protein β-2, Signal-Regulatory Protein β2, Signal-Regulatory Protein Beta-2, Signal-Regulatory Protein Beta 2, PTPNS1L3, PTPN1L, dJ776F14.2

Catalog No. TMPJ-01160 Copy Product Info

Signal-regulatory protein beta-2(SIRP-beta-2), is a monomeric single pass type I membrane glycoprotein, belongs to the SIRP/SHPS (CD172) family of the immunoglobulin (Ig) superfamily. The SIRP family are paired receptors that have similar extracellular domains but differing C-terminal domains and functions. A positively charged residue within the transmembrane domain, in analogy to SIRP-beta-1, is implicated to mediate interaction with the adaptor DAP12 protein, which contains immunoreceptor tyrosine-based activation motifs (ITAMs) . Proteins in the SIRP family are typically expressed in immune cells, especially in the myeloid lineages . Based on expression patterns, SIRPs are thought to have roles in immune regulation. SIRP family members role in innate immunity and host defense has potential significance as a therapeutic target in cancer and inflammation. There are currently no known mouse or rat homologs for this protein.

SIRP beta 2 Protein, Human, Recombinant (hFc)

Pack Size	Price	USA Stock	Global Stock
5 μg	$39	35 days	35 days
10 μg	$60	35 days	35 days
20 μg	$96	35 days	35 days
50 μg	$183	35 days	35 days
100 μg	$332	35 days	35 days
200 μg	$592	35 days	35 days
500 μg	$1,350	35 days	35 days
1 mg	$2,010	35 days	35 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity


Description	Signal-regulatory protein beta-2(SIRP-beta-2), is a monomeric single pass type I membrane glycoprotein, belongs to the SIRP/SHPS (CD172) family of the immunoglobulin (Ig) superfamily. The SIRP family are paired receptors that have similar extracellular domains but differing C-terminal domains and functions. A positively charged residue within the transmembrane domain, in analogy to SIRP-beta-1, is implicated to mediate interaction with the adaptor DAP12 protein, which contains immunoreceptor tyrosine-based activation motifs (ITAMs) . Proteins in the SIRP family are typically expressed in immune cells, especially in the myeloid lineages . Based on expression patterns, SIRPs are thought to have roles in immune regulation. SIRP family members role in innate immunity and host defense has potential significance as a therapeutic target in cancer and inflammation. There are currently no known mouse or rat homologs for this protein.
Species	Human
Expression System	HEK293 Cells
Tag	C-hFc
Accession Number	Q5JXA9
Amino Acid	Gln33-Gly287
Construction	Gln33-Gly287
Protein Purity	Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin	< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4.
Reconstitution	Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Synonyms	SIRP-β-2, SIRPG, SIRP-beta-2, SIRP β2, SIRP beta 2, Signal-Regulatory Protein β-2, Signal-Regulatory Protein β2, Signal-Regulatory Protein Beta-2, Signal-Regulatory Protein Beta 2, PTPNS1L3, PTPN1L, dJ776F14.2
Research Background

Chemical Properties

Molecular Weight

80-95 KDa (reducing condition)

Storage & Solubility Information

Storage

Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SIRP-b-2SIRP β 2SIRP b 2Signal-Regulatory Protein β 2Signal-Regulatory Protein b-2Signal-Regulatory Protein b 2

Related Tags: SIRP beta 2 Protein, Human, Recombinant (hFc) chemical structure | SIRP beta 2 Protein, Human, Recombinant (hFc) molecular weight