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Diclofenac

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Catalog No. T0196Cas No. 15307-86-5
Alias Voltaren, Diclofenacum

Diclofenac (Diclofenacum) is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. Diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins.

Diclofenac
Other Forms of Diclofenac:

Diclofenac

🥰Excellent
Purity: 99.97%
Catalog No. T0196Alias Voltaren, DiclofenacumCas No. 15307-86-5
Diclofenac (Diclofenacum) is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. Diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins.
Pack SizePriceAvailabilityQuantity
500 mg$42In Stock
5 g$51In Stock
10 g$83In Stock
1 mL x 10 mM (in DMSO)$46In Stock
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Purity:99.97%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
Diclofenac (Diclofenacum) is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. Diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins.
Targets&IC50
COX-1 (human, CHO cells):4 nM, COX-1 (ovine):0.84 μM, COX-1 (ovine):5.1 μM, COX-2 (human, CHO cells):1.3 nM
SynonymsVoltaren, Diclofenacum
Chemical Properties
Molecular Weight296.15
FormulaC14H11Cl2NO2
Cas No.15307-86-5
SmilesOC(=O)CC1=C(NC2=C(Cl)C=CC=C2Cl)C=CC=C1
Relative Density.1.431 g/cm3
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 160 mg/mL (540.27 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.3767 mL16.8833 mL33.7667 mL168.8334 mL
5 mM0.6753 mL3.3767 mL6.7533 mL33.7667 mL
10 mM0.3377 mL1.6883 mL3.3767 mL16.8833 mL
20 mM0.1688 mL0.8442 mL1.6883 mL8.4417 mL
50 mM0.0675 mL0.3377 mL0.6753 mL3.3767 mL
100 mM0.0338 mL0.1688 mL0.3377 mL1.6883 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

stemovineNSCsneuralInhibitorinhibitDiclofenacCyclooxygenaseCOX-2COX-1COXCHOcellscaspasecascadeApoptosisanti-inflammatory
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