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Anti-CD3 zeta/CD247 Antibody (4V394)
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Catalog No. TMAY-02501
Alias TCRZ, T3Z, IMD25, CD3-ζ, CD3-ZETA, CD3Z, CD3Q, CD3H, CD3 ζ/CD247, CD247 molecule
Anti-CD3 zeta/CD247 Antibody (4V394) is a Mouse antibody targeting CD3 zeta/CD247. Anti-CD3 zeta/CD247 Antibody (4V394) can be used in FCM.
Anti-CD3 zeta/CD247 Antibody (4V394)
Anti-CD3 zeta/CD247 Antibody (4V394)
😃Good
Catalog No. TMAY-02501Alias TCRZ, T3Z, IMD25, CD3-ζ, CD3-ZETA, CD3Z, CD3Q, CD3H, CD3 ζ/CD247, CD247 molecule
Anti-CD3 zeta/CD247 Antibody (4V394) is a Mouse antibody targeting CD3 zeta/CD247. Anti-CD3 zeta/CD247 Antibody (4V394) can be used in FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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| Description | Anti-CD3 zeta/CD247 Antibody (4V394) is a Mouse antibody targeting CD3 zeta/CD247. Anti-CD3 zeta/CD247 Antibody (4V394) can be used in FCM. |
| Alias | TCRZ, T3Z, IMD25, CD3-ζ, CD3-ZETA, CD3Z, CD3Q, CD3H, CD3 ζ/CD247, CD247 molecule |
| Ig Type | Monoclonal Mouse IgG2a |
| Clone | 4V394 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human CD3 Zeta expression on human whole blood lymphocytes.The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), stained with purified anti-Human CD3 Zeta, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes. |
| Application | FCM |
| Recommended Dose | FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD3 zeta / CD247 (rh CD3 zeta / CD247; TMPY-02960; P20963-1; Arg52-Arg164). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | CD247, also known as CD3-ZETA, belongs to the CD3Z/FCER1G family. It contains 3 ITAM domains. As a -cell receptor zeta, CD247 forms the T-cell receptor-CD3 complex together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and –epsilon. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for CD247 gene. Defects in CD247 can cause immunodeficiency due to defect in CD3-zeta. An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens. CD247 may play a role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering. |
| Conjucates | Unconjugated |
| Others Formats | FITC/PE |
| Antibody Types Available | 3 |
| Immunogen | Recombinant Human CD3 zeta / CD247 Protein (TMPY-02960) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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