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trans-Pralsetinib (Synonyms: trans-BLU-667)

Name: trans-Pralsetinib
Brand: TargetMol
SKU: T10823
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T10823 Copy Product Info

Purity: 98.06%

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trans-Pralsetinib (trans-BLU-667) is a potent inhibitor of the RET (Rearranged during Transfection) kinase. This compound originates from Compound Example 129 in patent US20170121312A1. RET is a receptor tyrosine kinase whose genetic rearrangements or mutations are key drivers in various cancers, including non-small cell lung cancer (NSCLC) and medullary thyroid cancer. By inhibiting RET kinase activity, trans-Pralsetinib blocks downstream oncogenic signaling pathways, thereby exerting anti-tumor effects.

trans-Pralsetinib

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Catalog No. T10823

Synonyms trans-BLU-667

Cas No. 2097132-93-7

Pack Size	Price	USA Stock	Global Stock	Quantity
2 mg	$64	-	In Stock
1 mL x 10 mM (in DMSO)	$29	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:98.06%

Appearance:Viscous

Color:Transparent

Resource Download

COA MS HNMR HPLC

Product Introduction

Bioactivity

Description

Synonyms

trans-BLU-667

Chemical Properties

Molecular Weight	533.6
Formula	C₂₇H₃₂FN₉O₂
Cas No.	2097132-93-7
Smiles	C(N[C@@H](C)C=1C=CC(=NC1)N2N=CC(F)=C2)(=O)[C@]3(OC)CC[C@@H](CC3)C=4N=C(NC5=NNC(C)=C5)C=C(C)N4
Relative Density.	1.40 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (149.93 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8741 mL	9.3703 mL	18.7406 mL	93.7031 mL
5 mM	0.3748 mL	1.8741 mL	3.7481 mL	18.7406 mL
10 mM	0.1874 mL	0.9370 mL	1.8741 mL	9.3703 mL
20 mM	0.0937 mL	0.4685 mL	0.9370 mL	4.6852 mL
50 mM	0.0375 mL	0.1874 mL	0.3748 mL	1.8741 mL
100 mM	0.0187 mL	0.0937 mL	0.1874 mL	0.9370 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Citations

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Dilution Calculator
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Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc