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Mab Aspartate Decarboxylase-IN-1
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Catalog No. T60613Cas No. 2755712-12-8
Mab Aspartate Decarboxylase-IN-1 is a potent inhibitor of aspartate decarboxylase (PanD) with an IC50 of 56.3 μM and exhibits antibacterial activity [1].
Mab Aspartate Decarboxylase-IN-1
😃Good
Catalog No. T60613Cas No. 2755712-12-8
Mab Aspartate Decarboxylase-IN-1 is a potent inhibitor of aspartate decarboxylase (PanD) with an IC50 of 56.3 μM and exhibits antibacterial activity [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $116 | 5 days | 5 days | |
| 50 mg | $789 | 6-8 weeks | 6-8 weeks | |
| 100 mg | $1,240 | 6-8 weeks | 6-8 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Mab Aspartate Decarboxylase-IN-1 is a potent inhibitor of aspartate decarboxylase (PanD) with an IC50 of 56.3 μM and exhibits antibacterial activity [1]. |
| In vitro | Mab Aspartate Decarboxylase-IN-1 (compound analogue 2) effectively inhibits Mab PanDE119A, Mab PanDS135A, and Mab PanDY126A mutants with rates of 70.5%, 74.4%, and 81.8%, respectively [1]. At 0-200 μM, it inhibits the Mycobacterium abscessus (Mab) PanD enzyme, converting l-Aspartate to β-Alanine, with an IC50 of 56.3±4.8 μM [1]. At 0-4 mM concentrations, it exhibits antibacterial activity against various M. abscessus subspecies, specifically an IC50 of 0.7 mM for M. abscessus subsp. abscessus ATCC 19977, and IC50 values of 1-2 mM for M. abscessus subsp. bolletii CCUG 50184T, M. abscessus subsp. massiliense CCUG 48898T, M. abscessus subsp. abscessus Bamboo, and M. abscessus subsp. abscessus ATCC 19977 [1]. The compound’s interaction with the target enzyme is primarily through electrostatic and hydrogen bonding [1]. |
| Molecular Weight | 293.28 |
| Formula | C16H11N3O3 |
| Cas No. | 2755712-12-8 |
| Smiles | OC(=O)c1nccnc1NC(=O)c1cccc2ccccc12 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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