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Mab Aspartate Decarboxylase-IN-1

Catalog No. T60613 CAS 2755712-12-8

Mab Aspartate Decarboxylase-IN-1 is a potent inhibitor of aspartate decarboxylase (PanD) (IC50 = 56.3 μM) with antibacterial activity [1].

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Mab Aspartate Decarboxylase-IN-1 Chemical Structure

Mab Aspartate Decarboxylase-IN-1, CAS 2755712-12-8

Pack Size	Availability	Price/USD
2 mg	5 days	$ 116.00
50 mg	6-8 weeks	$ 789.00
100 mg	6-8 weeks	$ 1,240.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Mab Aspartate Decarboxylase-IN-1 is a potent inhibitor of aspartate decarboxylase (PanD) (IC50 = 56.3 μM) with antibacterial activity [1].

In vitro

Mab Aspartate Decarboxylase-IN-1 (compound analogue 2) demonstrates inhibition effects on the Mab PanDE119A, Mab PanDS135A, and Mab PanDY126A mutants with inhibition rates of 70.5%, 74.4%, and 81.8%, respectively [1]. At concentrations ranging from 0-200 μM, it inhibits the activity of the Mycobacterium abscessus (Mab) PanD enzyme, which is involved in converting l-Aspartate to β-Alanine, displaying an IC50 value of 56.3±4.8 μM [1]. Additionally, when tested in concentrations from 0-4 mM, Mab Aspartate Decarboxylase-IN-1 exhibits antibacterial activity against various M. abscessus subspecies, specifically showing an IC50 value of 0.7 mM for M. abscessus subsp. abscessus ATCC 19977 and IC50 values ranging from 1-2 mM for M. abscessus subsp. bolletii CCUG 50184T, M. abscessus subsp. massiliense CCUG 48898T, M. abscessus subsp. abscessus Bamboo, and M. abscessus subsp. abscessus ATCC 19977 [1]. The compound’s interaction with the target enzyme is chiefly characterized by electrostatic and hydrogen bonding [1].

Molecular Weight	293.28
Formula	C16H11N3O3
CAS No.	2755712-12-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Mab Aspartate Decarboxylase-IN-1 2755712-12-8 inhibitor inhibit

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