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TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (His)
(Synonyms: tumor necrosis factor receptor superfamily, member 1b, TNFα-R2, TNF-αR2, TNF-R-II, TNFRII, TNFR80, TNF-R75, TNF-R2, Tnfr2, Tnfr-1, TNFBR, TNFalpha-R2, TNF-alphaR2, p75, CD120b) Copy Product InfoSynonyms: tumor necrosis factor receptor superfamily, member 1b, TNFα-R2, TNF-αR2, TNF-R-II, TNFRII, TNFR80, TNF-R75, TNF-R2, Tnfr2, Tnfr-1, TNFBR, TNFalpha-R2, TNF-alphaR2, p75, CD120b
Catalog No. TMPY-01697 Copy Product Info
TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.8 kDa and the accession number is P25119.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 µg | $48 | - | In Stock | |
| 10 µg | $75 | 7-10 days | 7-10 days | |
| 20 µg | $118 | - | In Stock | |
| 50 µg | $229 | 7-10 days | 7-10 days | |
| 100 µg | $386 | - | In Stock | |
| 200 µg | $682 | 7-10 days | 7-10 days | |
| 500 µg | $1,430 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:SDS-PAGE: 97.9%; SEC-HPLC: 99.6%
Appearance:Lyophilized powder
Color:White
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Product Information
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Measured by its ability to inhibit TNFα-mediated cytotoxicity in L-929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D. The ED50 for this effect is typically 1-3 μg/mL in the presence of 0.1 ng/mL of recombinant mouse TNFα. |
| Description | TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.8 kDa and the accession number is P25119. |
| Species | Mouse |
| Expression System | HEK293 Cells |
| Tag | C-His |
| Accession Number | P25119 |
| Construction | A DNA sequence encoding the extracellular domain of mouse TNFRSF1B (NP_035740.2) (Met 1-Gly 258) was fused with a polyhistidine tag at the C-terminus. Predicted N terminal: Val 23 |
| Protein Purity | > 97 % as determined by SDS-PAGE. ≥90 % as determined by SEC-HPLC.  , |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot. |
| Synonyms | tumor necrosis factor receptor superfamily, member 1b, TNFα-R2, TNF-αR2, TNF-R-II, TNFRII, TNFR80, TNF-R75, TNF-R2, Tnfr2, Tnfr-1, TNFBR, TNFalpha-R2, TNF-alphaR2, p75, CD120b |
| Research Background | Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B), also known as Tumor necrosis factor receptor 2 (TNFR2) or CD120b antigen, is a member of the tumor necrosis factor receptor superfamily. TNFR2/CD120b/TNFRSF1B is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. TNFR2/CD120b/TNFRSF1B is not a major contributing factor to the genetic risk of type 2 diabetes, its associated peripheral neuropathy and hypertension and related metabolic traits in North Indians. Tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) has been reported to be associated with SLE risk in Japanese populations. TNFR2/CD120b/TNFRSF1B serves as a receptor with high affinity for TNFSF2 and approximately 5-fold lower affinity for homotrimeric TNFSF1. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Molecular Weight | 26.8 kDa (predicted); 45 kDa (reducing condition, due to glycosylation) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (His) chemical structure | TNFR2/CD120b/TNFR1B Protein, Mouse, Recombinant (His) molecular weight
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