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17(S)-HETE

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Catalog No. T35849Cas No. 183509-25-3

17(S)-HETE is an arachidonic acid metabolite generated via the CYP450 pathway. 17(S)-HETE acts as an allosteric activator of CYP450 1B1 and an ATPase inhibitor, capable of inducing cardiac hypertrophy.

17(S)-HETE
Other Forms of 17(S)-HETE:

17(S)-HETE

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Catalog No. T35849Cas No. 183509-25-3
17(S)-HETE is an arachidonic acid metabolite generated via the CYP450 pathway. 17(S)-HETE acts as an allosteric activator of CYP450 1B1 and an ATPase inhibitor, capable of inducing cardiac hypertrophy.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 μg$52935 days35 days
50 μg$98735 days35 days
100 μg$1,89035 days35 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
17(S)-HETE is an arachidonic acid metabolite generated via the CYP450 pathway. 17(S)-HETE acts as an allosteric activator of CYP450 1B1 and an ATPase inhibitor, capable of inducing cardiac hypertrophy.
In vitro
17(S)-HETE (5-20 μM) can promote the activity and protein expression of CY1B1, ultimately accelerating the process of cardiac hypertrophy in Homo sapiens [1].
In vivo
After administering 17(S)-HETE (1-20 μg) via arterial injection to New Zealand white rabbits, the ATPase activity in their proximal renal tubules was significantly inhibited [2].
Chemical Properties
Molecular Weight320.47
FormulaC20H32O3
Cas No.183509-25-3
SmilesC(=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O)\C[C@H](CCC)O
ColorTransparent
AppearanceLiquid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
0.1 M Na2CO3: 1.00 mg/mL (3.12 mM), Sonication is recommended.
PBS (pH 7.2): 0.40 mg/mL (1.25 mM), Sonication is recommended.
Ethanol: Miscible
DMSO: Miscible
DMF: Miscible
Solution Preparation Table
PBS (pH 7.2)/0.1 M Na2CO3
1mg5mg10mg50mg
1 mM3.1204 mL15.6021 mL31.2042 mL156.0208 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

17HETE17(S)HETE17(S) HETE
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