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Compound 3344 hydrochloride

Name: Compound 3344 hydrochloride
Brand: TargetMol
SKU: T9184L
Price: 146 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9184L

Alias Compound 3344 hydrochloride (2368246-78-8 free base)

Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions,with an affnity of 126nM.

Compound 3344 hydrochloride

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Purity: 99.23%

Catalog No. T9184LAlias Compound 3344 hydrochloride (2368246-78-8 free base)

Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions,with an affnity of 126nM.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$146	In Stock	In Stock
5 mg	$298	In Stock	In Stock
10 mg	$448	In Stock	In Stock
25 mg	$739	In Stock	In Stock
50 mg	$987	In Stock	In Stock
100 mg	$1,380	-	In Stock
1 mL x 10 mM (in DMSO)	$353	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.23%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR HPLC LCMS

Product Introduction

Bioactivity

Description	Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions,with an affnity of 126nM.
In vitro	In vitro competition studies of 3344 hydrochloride binding to KRAS-G12V in waterLOGSY NMR show the anti-RAS scFv inhibits 3344 hydrochloride binding to KRAS. In view of the in vitro inhibition by the anti-RAS scFv of 3344 hydrochloride binding to RASand because the iDAb RAS interferes with BRET signal in cells, 3344 hydrochloride was used for validation of the BRET2 toolbox for RAS-effector PPI inhibitors.
Synonyms	Compound 3344 hydrochloride (2368246-78-8 free base)

Chemical Properties

Molecular Weight	426.94
Formula	C₂₄H₂₇ClN₂O₃
Smiles	COC1=CC(C2=C3OCCOC3=CC=C2)=CC=C1NC4=CC=CC(CN(C)C)=C4.[H]Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (140.53 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3422 mL	11.7112 mL	23.4225 mL	117.1125 mL
5 mM	0.4684 mL	2.3422 mL	4.6845 mL	23.4225 mL
10 mM	0.2342 mL	1.1711 mL	2.3422 mL	11.7112 mL
20 mM	0.1171 mL	0.5856 mL	1.1711 mL	5.8556 mL
50 mM	0.0468 mL	0.2342 mL	0.4684 mL	2.3422 mL
100 mM	0.0234 mL	0.1171 mL	0.2342 mL	1.1711 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc