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Compound 3344 hydrochloride

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Catalog No. T9184L
Alias Compound 3344 hydrochloride (2368246-78-8 free base)

Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions,with an affnity of 126nM.

Compound 3344 hydrochloride
Other Forms of Compound 3344 hydrochloride:
pan-KRAS-IN-16T91842368246-78-8
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Compound 3344 hydrochloride

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Purity: 99.23%
Catalog No. T9184LAlias Compound 3344 hydrochloride (2368246-78-8 free base)
Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions,with an affnity of 126nM.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$146In StockIn Stock
5 mg$298In StockIn Stock
10 mg$448In StockIn Stock
25 mg$739In StockIn Stock
50 mg$987In StockIn Stock
100 mg$1,380-In Stock
1 mL x 10 mM (in DMSO)$353In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:99.23%
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Product Introduction

Bioactivity
Description
Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions,with an affnity of 126nM.
In vitro
In vitro competition studies of 3344 hydrochloride binding to KRAS-G12V in waterLOGSY NMR show the anti-RAS scFv inhibits 3344 hydrochloride binding to KRAS. In view of the in vitro inhibition by the anti-RAS scFv of 3344 hydrochloride binding to RASand because the iDAb RAS interferes with BRET signal in cells, 3344 hydrochloride was used for validation of the BRET2 toolbox for RAS-effector PPI inhibitors.
SynonymsCompound 3344 hydrochloride (2368246-78-8 free base)
Chemical Properties
Molecular Weight426.94
FormulaC24H27ClN2O3
SmilesCOC1=CC(C2=C3OCCOC3=CC=C2)=CC=C1NC4=CC=CC(CN(C)C)=C4.[H]Cl
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (140.53 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3422 mL11.7112 mL23.4225 mL117.1125 mL
5 mM0.4684 mL2.3422 mL4.6845 mL23.4225 mL
10 mM0.2342 mL1.1711 mL2.3422 mL11.7112 mL
20 mM0.1171 mL0.5856 mL1.1711 mL5.8556 mL
50 mM0.0468 mL0.2342 mL0.4684 mL2.3422 mL
100 mM0.0234 mL0.1171 mL0.2342 mL1.1711 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

KRASCompound 3344 HydrochlorideCompound 3344 hydrochloride2368246-78-8 free base2368246-78-8
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