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Methacholine Chloride

🥰Excellent
Catalog No. T1682Cas No. 62-51-1
Alias Mecholyl chloride, Acetyl-β-methylcholine chloride

Methacholine Chloride (Acetyl-β-methylcholine chloride) is a quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma.

Methacholine Chloride
Other Forms of Methacholine Chloride:

Methacholine Chloride

🥰Excellent
Purity: 99.74%
Catalog No. T1682Alias Mecholyl chloride, Acetyl-β-methylcholine chlorideCas No. 62-51-1
Methacholine Chloride (Acetyl-β-methylcholine chloride) is a quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma.
Pack SizePriceAvailabilityQuantity
25 mg$32In Stock
50 mg$43In Stock
100 mg$59In Stock
500 mg$142In Stock
1 g$198In Stock
1 mL x 10 mM (in DMSO)$47In Stock
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Purity:99.74%
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Product Introduction

Bioactivity
Description
Methacholine Chloride (Acetyl-β-methylcholine chloride) is a quaternary ammonium parasympathomimetic agent with the muscarinic actions of ACETYLCHOLINE. It is hydrolyzed by ACETYLCHOLINESTERASE at a considerably slower rate than ACETYLCHOLINE and is more resistant to hydrolysis by nonspecific CHOLINESTERASES so that its actions are more prolonged. It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma.
SynonymsMecholyl chloride, Acetyl-β-methylcholine chloride
Chemical Properties
Molecular Weight195.69
FormulaC8H18ClNO2
Cas No.62-51-1
Smiles[Cl-].CC(C[N+](C)(C)C)OC(C)=O
Relative Density.1.1028 g/cm3 (Estimated)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (255.51 mM), Sonication is recommended.
H2O: 100 mg/mL (511.01 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM5.1101 mL25.5506 mL51.1012 mL255.5062 mL
5 mM1.0220 mL5.1101 mL10.2202 mL51.1012 mL
10 mM0.5110 mL2.5551 mL5.1101 mL25.5506 mL
20 mM0.2555 mL1.2775 mL2.5551 mL12.7753 mL
50 mM0.1022 mL0.5110 mL1.0220 mL5.1101 mL
100 mM0.0511 mL0.2555 mL0.5110 mL2.5551 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

Muscarinic acetylcholine receptorMethacholine ChlorideMethacholineMecholyl ChloridemAChRInhibitorinhibitbronchoconstrictionasthma-likeairway hyperresponsivenessAcetyl-β-methylcholine ChlorideAcetyl-b-methylcholine ChlorideAcetyl-beta-methylcholine Chloride
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