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Claudin-18 Protein, Human, Recombinant (CLDN18.2), Fluorescent

Catalog No. TMPY-06822
Synonyms: SFTPJ, claudin 18, SFTA5

Claudins family member Claudin18 (CLDN18) is a four-pass transmembrane protein with two extracellular loops and cytoplasmic N- and C-tails found in tight junctions. CLDN18 modulates paracellular permeability, polarity, and signaling. CLDN18 deficiency has been associated with atrophic gastritis, spasmolytic polypeptide-expressing metaplasia (SPEM), and asthma. Lung-specific CLDN18.1 modulates alveolar epithelial type II (AT2) cell proliferation and organ size. Restoration of CLDN18.1 expression in human lung cancer cells has been shown to suppress proliferation, inhibiting the IGF-1R/AKT axes. Not expressed in other healthy tissues, gastric mucosa-specific isoform CLDN18.2 expression manifests in primary gastric cancers. CLDN18.2 at the surface of epithelial tumor cells is a target in antibody and CAR-therapies currently in development.

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Claudin-18 Protein, Human, Recombinant (CLDN18.2), Fluorescent
Pack Size Availability Price/USD Quantity
20 μg 5 days $ 1,000.00
100 μg 5 days $ 2,110.00
500 μg 5 days $ 7,450.00
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Biological Description
Technical Params
Product Properties
Description Claudins family member Claudin18 (CLDN18) is a four-pass transmembrane protein with two extracellular loops and cytoplasmic N- and C-tails found in tight junctions. CLDN18 modulates paracellular permeability, polarity, and signaling. CLDN18 deficiency has been associated with atrophic gastritis, spasmolytic polypeptide-expressing metaplasia (SPEM), and asthma. Lung-specific CLDN18.1 modulates alveolar epithelial type II (AT2) cell proliferation and organ size. Restoration of CLDN18.1 expression in human lung cancer cells has been shown to suppress proliferation, inhibiting the IGF-1R/AKT axes. Not expressed in other healthy tissues, gastric mucosa-specific isoform CLDN18.2 expression manifests in primary gastric cancers. CLDN18.2 at the surface of epithelial tumor cells is a target in antibody and CAR-therapies currently in development.
Species Human
Expression System HEK293
Tag Tag Free
Accession Number P56856-2
Synonyms SFTPJ, claudin 18, SFTA5
Construction A DNA sequence encoding the human CLDN18 (P56856-2) (Met1-Val261) was expressed. This protein carries a GFP tag.
Molecular Weight Approxiamtely 54.74 kDa
Endotoxin < 1.0 EU per μg protein as determined by the LAL method.
Formulation Supplied as sterile 50mM Hepes, 150mM NaCl, 10% Trehalose, pH 7.2. Please contact us for any concerns or special requirements. Please refer to the specific buffer information in the hard copy of CoA.
Stability & Storage

Samples are stable for up to twelve months from date of receipt at -70℃. Store it under sterile conditions at -70℃ or lower. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping

It is supplied and shipped as Solution with dry ice.

Research Background Claudins family member Claudin18 (CLDN18) is a four-pass transmembrane protein with two extracellular loops and cytoplasmic N- and C-tails found in tight junctions. CLDN18 modulates paracellular permeability, polarity, and signaling. CLDN18 deficiency has been associated with atrophic gastritis, spasmolytic polypeptide-expressing metaplasia (SPEM), and asthma. Lung-specific CLDN18.1 modulates alveolar epithelial type II (AT2) cell proliferation and organ size. Restoration of CLDN18.1 expression in human lung cancer cells has been shown to suppress proliferation, inhibiting the IGF-1R/AKT axes. Not expressed in other healthy tissues, gastric mucosa-specific isoform CLDN18.2 expression manifests in primary gastric cancers. CLDN18.2 at the surface of epithelial tumor cells is a target in antibody and CAR-therapies currently in development.

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Keywords

Claudin-18 Protein, Human, Recombinant (CLDN18.2), Fluorescent SFTPJ claudin 18 SFTA5 SFTA 5 SFTA-5 recombinant recombinant-proteins proteins protein

 

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