PAT-1251 Hydrochloride

Name: PAT-1251 Hydrochloride
Brand: TargetMol
SKU: T12371
Rating: 4.5 (1 reviews)

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Catalog No. T12371Cas No. 2098884-53-6

PAT-1251 Hydrochloride is a potent, selective, and oral inhibitor of lysyl oxidase-like 2 (LOXL2), targeting hLOXL2 and hLOXL3 with IC50 values of 0.71 and 1.17 μM, respectively.

PAT-1251 Hydrochloride

😃Good

Catalog No. T12371Cas No. 2098884-53-6

PAT-1251 Hydrochloride is a potent, selective, and oral inhibitor of lysyl oxidase-like 2 (LOXL2), targeting hLOXL2 and hLOXL3 with IC50 values of 0.71 and 1.17 μM, respectively.

Pack Size	Price	Availability
25 mg	$1,520	1-2 weeks
50 mg	$1,980	1-2 weeks
100 mg	$2,500	1-2 weeks

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Product Introduction

Bioactivity

Description	PAT-1251 Hydrochloride is a potent, selective, and oral inhibitor of lysyl oxidase-like 2 (LOXL2), targeting hLOXL2 and hLOXL3 with IC50 values of 0.71 and 1.17 μM, respectively.
Targets&IC50	LOXL3 (human):1.17 μM , LOXL2 (dog):0.16 μM , LOXL2 (rat):0.12 μM , LOXL2 (mouse):0.10 μM , LOXL2 (human):0.71 μM
In vitro	PAT-1251 shows highly selective for LOXL2 over other key members of the amine oxidase family, such as the copper-dependent amine oxidases semicarbazide-sensitive amine oxidase (SSAO) and diamine oxidase (DAO), in addition to the flavin-dependent monoamine oxidases A (MAO-A) and B (MAO-B), with <10% inhibition at 10 μM[1].

Chemical Properties

Molecular Weight	435.8
Formula	C₁₈H₁₈ClF₄N₃O₃
Cas No.	2098884-53-6
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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