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Isocitric acid
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Catalog No. T73769Cas No. 320-77-4
Alias Isocitrate, 1-Hydroxypropane-1,2,3-tricarboxylic acid
Isocitric acid (Isocitrate), an isomer of citric acid, is a substrate for citric acid cycle and an endogenous metabolite, which has potential for the treatment of Parkinson’s disease, Fe-deficiency anemia, and metabolic myopathies associated with a shortage of succinate dehydrogenase and aconitate hydratase, as well as the mutation of the gene of NADP-dependent isocitrate dehydrogenase 1 (IDH1).
Isocitric acid
😃Good
Catalog No. T73769Alias Isocitrate, 1-Hydroxypropane-1,2,3-tricarboxylic acidCas No. 320-77-4
Isocitric acid (Isocitrate), an isomer of citric acid, is a substrate for citric acid cycle and an endogenous metabolite, which has potential for the treatment of Parkinson’s disease, Fe-deficiency anemia, and metabolic myopathies associated with a shortage of succinate dehydrogenase and aconitate hydratase, as well as the mutation of the gene of NADP-dependent isocitrate dehydrogenase 1 (IDH1).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $1,380 | In Stock | |
| 5 mg | $3,429 | 7-10 days | |
| 10 mg | $4,800 | 7-10 days | |
| 25 mg | Inquiry | 7-10 days | |
| 50 mg | Inquiry | 7-10 days | |
| 100 mg | Inquiry | 7-10 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Isocitric acid (Isocitrate), an isomer of citric acid, is a substrate for citric acid cycle and an endogenous metabolite, which has potential for the treatment of Parkinson’s disease, Fe-deficiency anemia, and metabolic myopathies associated with a shortage of succinate dehydrogenase and aconitate hydratase, as well as the mutation of the gene of NADP-dependent isocitrate dehydrogenase 1 (IDH1). |
| In vivo | The researchers used rats as experimental subjects and administered high-purity monopotassium salt of Isocitric acid (99.9% purity) to rats with lead- and molybdenum-induced neurotoxicity for 14 consecutive days. The results showed that the compound significantly alleviated neurotoxic symptoms and improved the rats' learning and memory abilities. [1] |
| Alias | Isocitrate, 1-Hydroxypropane-1,2,3-tricarboxylic acid |
| Molecular Weight | 192.12 |
| Formula | C6H8O7 |
| Cas No. | 320-77-4 |
| Smiles | O=C(O)CC(C(=O)O)C(O)C(=O)O |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 80 mg/mL (416.41 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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