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IMB-808

Name: IMB-808
Brand: TargetMol
SKU: T25528
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T25528Cas No. 870768-70-0

Alias IMB808

IMB-808 is an LXRα/β dual agonist that promotes ABCA1 expression and cholesterol efflux without inducing lipidogenesis in HepG2 cells. IMB-808 can be used in atherosclerosis research.

IMB-808

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Purity: 99.93%

Catalog No. T25528Alias IMB808Cas No. 870768-70-0

IMB-808 is an LXRα/β dual agonist that promotes ABCA1 expression and cholesterol efflux without inducing lipidogenesis in HepG2 cells. IMB-808 can be used in atherosclerosis research.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$45	-	In Stock
5 mg	$73	-	In Stock
10 mg	$108	-	In Stock
25 mg	$196	-	In Stock
50 mg	$293	-	In Stock
100 mg	$483	-	In Stock
200 mg	$689	-	In Stock
1 mL x 10 mM (in DMSO)	$80	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.93%

Color:White to Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	IMB-808 is an LXRα/β dual agonist that promotes ABCA1 expression and cholesterol efflux without inducing lipidogenesis in HepG2 cells. IMB-808 can be used in atherosclerosis research.
Targets&IC50	LXRβ:0.53 μM (EC50), LXRα:0.15 μM (EC50)
In vitro	IMB-808 exhibited a significant dose-dependent effect in the concentration range of 0.001 μM to 30 μM by activating LXRβ with an EC50 of 0.53 μM. In addition, IMB-808 was able to activate LXRα in a dose-dependent manner in a luciferase reporter gene assay with the GAL4-pGL4-luc reporter plasmid with an EC50 of 0.15 μM. M.[1] IMB-808 (0 μM-10 μM; 18 hours) significantly increased the protein and mRNA levels of ABCG1 and ABCA1 in RAW264.7 macrophage. [1] IMB-808 (0.1 μM-10 μM; 24 h) enhanced cholesterol efflux capacity in a dose-dependent manner while decreasing cellular cholesterol concentration in cell lines. [1]
Synonyms	IMB808

Chemical Properties

Molecular Weight	380.32
Formula	C₁₈H₁₅F₃N₂O₄
Cas No.	870768-70-0
Smiles	O=C(C1=CC=C2OCCOC2=C1)N(C)CC(=O)NC3=CC=C(F)C(F)=C3F
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (525.87 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6294 mL	13.1468 mL	26.2936 mL	131.4682 mL
5 mM	0.5259 mL	2.6294 mL	5.2587 mL	26.2936 mL
10 mM	0.2629 mL	1.3147 mL	2.6294 mL	13.1468 mL
20 mM	0.1315 mL	0.6573 mL	1.3147 mL	6.5734 mL
50 mM	0.0526 mL	0.2629 mL	0.5259 mL	2.6294 mL
100 mM	0.0263 mL	0.1315 mL	0.2629 mL	1.3147 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc