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GX 201

Catalog No. T9647 CAS 1788071-27-1

Synonyms: GX-201

GX 201 is a selective NaV1.7 inhibitor, IC50 of < 3.2 nM for hNaV1.7.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

GX 201, CAS 1788071-27-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 131.00
5 mg	In stock	$ 328.00
10 mg	In stock	$ 493.00
25 mg	In stock	$ 788.00
50 mg	In stock	$ 1,120.00
100 mg	In stock	$ 1,490.00
500 mg	In stock	$ 2,960.00
1 mL * 10 mM (in DMSO)	In stock	$ 363.00

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Purity: 99.46%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GX 201 is a selective NaV1.7 inhibitor, IC50 of < 3.2 nM for hNaV1.7.
In vivo	GX 201 has a relatively long half-life in mice. GX 201 produces analgesia at a free plasma concentration about 3 times the IC50 for high-affinity channel block. GX 201 inhibits nociceptive responses induced by formalin and inflammatory pain caused by complete Freund’s adjuvant (CFA)[1].

Synonyms	GX-201
Molecular Weight	563
Formula	C25H27ClF4N2O4S
CAS No.	1788071-27-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (106.6 mM), Sonification is recommended.

References and Literature

1. Girish Bankar, et al. Selective Na V 1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain. Cell Rep. 2018 Sep 18;24(12):3133-3145.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Cancer Compound Library

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Dose Conversion

You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GX 201 1788071-27-1 Membrane transporter/Ion channel Sodium Channel GX-201 GX201 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.