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Ginisortamab
😃Good
Catalog No. T78320Cas No. 2390147-17-6
Alias UCB-6114, UCB6114, UCB 6114
Ginisortamab (UCB6114) is a fully humanized monoclonal antibody targeting Gremlin-1, with IC50 values of 8.2 nM and 9 nM against human and mouse Gremlin-1, respectively. It inhibits Gremlin-1's antagonistic effect on BMP and is applicable for studying gastrointestinal tumors.
Ginisortamab
Ginisortamab
😃Good
Purity: 95%
Catalog No. T78320Alias UCB-6114, UCB6114, UCB 6114Cas No. 2390147-17-6
Ginisortamab (UCB6114) is a fully humanized monoclonal antibody targeting Gremlin-1, with IC50 values of 8.2 nM and 9 nM against human and mouse Gremlin-1, respectively. It inhibits Gremlin-1's antagonistic effect on BMP and is applicable for studying gastrointestinal tumors.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $332 | - | In Stock | |
| 5 mg | $863 | - | In Stock | |
| 10 mg | $1,380 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:96.0% (SDS-PAGE); 97.0% (SEC-HPLC)
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Target Gremlin-1
Antibody Information
| Description | Ginisortamab (UCB6114) is a fully humanized monoclonal antibody targeting Gremlin-1, with IC50 values of 8.2 nM and 9 nM against human and mouse Gremlin-1, respectively. It inhibits Gremlin-1's antagonistic effect on BMP and is applicable for studying gastrointestinal tumors. |
| In vitro | Ginisortamab (0.1-1000 nM) exhibited dose-dependent inhibitory effects on Homo sapiens and murine gremlin-1, with mean IC50 values of 8.2 nM (Homo sapiens-derived) and 9 nM (murine-derived), respectively [2]. The geometric mean binding affinities of Ginisortamab for Homo sapiens and murine gremlin-1 were 87 pM and 61 pM, respectively [2]. Ginisortamab (150 nM, 30-120 minutes) effectively blocked the antagonistic effect of gremlin-1 on the BMP signaling pathway in Homo sapiens colorectal cancer cells (CRC) and fibroblasts [2]. |
| Synonyms | UCB-6114, UCB6114, UCB 6114 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID |
| Cas No. | 2390147-17-6 |
| Color | Transparent |
| Appearance | Liquid |
| Isotype | Human IgG4 kappa |
| Recommended Isotype Control |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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