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Anisindione

Name: Anisindione
Brand: TargetMol
SKU: T14291
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14291Cas No. 117-37-3

Anisindione is a synthetic anticoagulant and an indanedione derivative. It prevents the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagulant proteins C and S, in the liver by inhibiting the vitamin K–mediated gamma-carboxylation of precursor proteins.

Anisindione

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Purity: 98.25%

Catalog No. T14291Cas No. 117-37-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
50 mg	$33	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:98.25%

Appearance:Solid

Color:White

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COA HNMR HPLC LCMS

Product Introduction

Anisindione AI Summary

Anisindione exhibits a wide array of bioactivities spanning various biological systems and assays. It inhibits the binding of Batrachotoxinin [3H]BTX-B to high-affinity sites on voltage-dependent sodium channels in guinea pig cerebral cortex with minimal inhibition at higher concentrations. In RBL-1 cells, it inhibits 5-lipoxygenase activity with an IC50 value of 9100.0 nM. In in vivo studies on CF1 male mice and Sprague-Dawley rats, Anisindione demonstrates hypolipidemic activity by reducing serum cholesterol and triglyceride levels, and affecting key liver enzymes involved in lipid metabolism. Furthermore, it exhibits diverse bioactivity such as modulating miRNAs, enhancing SMN2 splice variant expression, inhibiting Tau fibril formation, and showing cytotoxicity toward p53-mutant cancer cells. It acts on various receptors and enzymes, indicating potential effects on neurotransmitter systems, inhibiting viral entries like Ebola and Hepatitis C Virus, and inhibiting Histone Lysine Methyltransferase G9a. In terms of antiviral properties, Anisindione shows activity against SARS-CoV-2, inhibiting virus-induced cytotoxicity in Caco-2 and Vero E6 cells, despite demonstrating relatively low inhibition percentages and high IC50 values in some assays. It also inhibits SARS-CoV-2 3CL-Pro protease by 9.717% at 20µM concentration. Biochemically, Anisindione impairs oxidative phosphorylation in rat liver mitochondria, significantly inhibits sodium fluorescein uptake in OATP1B1/1B3-transfected CHO cells, shows potential as an HDAC6 inhibitor with high inhibition rates, and affects several markers related to liver and kidney function, as well as blood chemistry parameters. Thus, Anisindione holds promise for various therapeutic and biochemical applications due to its multifaceted bioactivity..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	252.26
Formula	C₁₆H₁₂O₃
Cas No.	117-37-3
Smiles	COc1ccc(cc1)C1C(=O)c2ccccc2C1=O
Relative Density.	1.1824 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (198.21 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.93 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9642 mL	19.8208 mL	39.6416 mL	198.2082 mL
5 mM	0.7928 mL	3.9642 mL	7.9283 mL	39.6416 mL
10 mM	0.3964 mL	1.9821 mL	3.9642 mL	19.8208 mL
20 mM	0.1982 mL	0.9910 mL	1.9821 mL	9.9104 mL
50 mM	0.0793 mL	0.3964 mL	0.7928 mL	3.9642 mL
100 mM	0.0396 mL	0.1982 mL	0.3964 mL	1.9821 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc