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Zafirlukast

Name: Zafirlukast
Brand: TargetMol
SKU: T6736
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6736Cas No. 107753-78-6

Alias Vanticon, ICI 204219, Accolate

Zafirlukast (ICI 204219) is an orally active leukotriene D4 receptor (LTD4) antagonist (IC50=0.6 μM). Zafirlukast has anti-asthmatic, anti-inflammatory, and antimicrobial properties and is used in the prevention and treatment of asthma.

Zafirlukast

🥰Excellent

Purity: 99.83%

Catalog No. T6736Alias Vanticon, ICI 204219, AccolateCas No. 107753-78-6

Pack Size	Price	Availability
10 mg	$30	In Stock
25 mg	$45	In Stock
50 mg	$64	In Stock
100 mg	$93	In Stock
500 mg	$277	In Stock
1 mL x 10 mM (in DMSO)	$56	In Stock

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Purity:99.83%

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COA

Product Introduction

Bioactivity

Description	Zafirlukast (ICI 204219) is an orally active leukotriene D4 receptor (LTD4) antagonist (IC50=0.6 μM). Zafirlukast has anti-asthmatic, anti-inflammatory, and antimicrobial properties and is used in the prevention and treatment of asthma.
In vitro	METHODS: Loucy cells were treated with THZ1 (0.8-500 nM) for 4 h. Binding was detected by LanthaScreen Eu Kinase Binding assay. RESULTS: THZ1 showed time-dependent inhibition of CDK7 in vitro and covalent binding of intracellular CDK7. [1] METHODS: NSCLC cell lines H1299, A549 and H292 were treated with THZ1 (10-10000 nM) for 48 h. Cell viability was measured by crystal violet assay. RESULTS: THZ1 dose-dependently inhibited the migration and proliferation of NSCLC cells. [2]
In vivo	METHODS: To detect anti-tumor activity in vivo, THZ1 (10 mg/kg) was injected intravenously twice daily for 28 days into NU/NU mice bearing MYCN-amplified human NB xenografts. RESULTS: THZ1 inhibited tumor growth in the human MYCN-amplified NB mouse model. [3] METHODS: To detect the antitumor activity in vivo, THZ1 (10 mg/kg) was injected intraperitoneally into NSG mice bearing KYSE510 tumors twice daily for 24 days. RESULTS: THZ1 inhibited the growth of KYSE510 xenografts and suppressed lung metastasis in the NSG mouse model. [4]
Synonyms	Vanticon, ICI 204219, Accolate

Chemical Properties

Molecular Weight	575.68
Formula	C₃₁H₃₃N₃O₆S
Cas No.	107753-78-6
Smiles	COc1cc(ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1C
Relative Density.	1.32 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 105 mg/mL (182.39 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (6.95 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7371 mL	8.6854 mL	17.3708 mL	86.8538 mL
5 mM	0.3474 mL	1.7371 mL	3.4742 mL	17.3708 mL
10 mM	0.1737 mL	0.8685 mL	1.7371 mL	8.6854 mL
20 mM	0.0869 mL	0.4343 mL	0.8685 mL	4.3427 mL
50 mM	0.0347 mL	0.1737 mL	0.3474 mL	1.7371 mL
100 mM	0.0174 mL	0.0869 mL	0.1737 mL	0.8685 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc