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BI-2493

Name: BI-2493
Brand: TargetMol
SKU: T72061
Price: 538 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T72061Cas No. 2937344-16-4

BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.BI-2493 exhibits antitumor activity and inhibits tumor cell growth and can be used in the study of cancerous diseases.BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.

BI-2493

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Purity: 99.88%

Catalog No. T72061Cas No. 2937344-16-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$538	In Stock	In Stock
5 mg	$1,070	In Stock	In Stock
10 mg	$1,480	In Stock	In Stock
25 mg	$2,470	In Stock	In Stock
50 mg	$3,290	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$1,580	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.88%

ee:100%

Appearance:Solid

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COA CSFC HNMR LCMS

Product Introduction

Bioactivity

Description	BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.BI-2493 exhibits antitumor activity and inhibits tumor cell growth and can be used in the study of cancerous diseases.BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.
Targets&IC50	HSKTC cells:130.0 nM, HuG1-N cells:59.1 nM, KRAS (G12D):2 nM, SNU-245 cells:136.1 nM, SAS cells:413.4 nM, KRAS (G12V):11 nM, KRas (G12C):3 nM
In vitro	METHODS: ASPC1, HPAC and H727 cells were treated with BI-2493 (Log (1-4nM)), and cell viability was detected after 72 hours. RESULTS BI-2493 inhibited the growth of ASPC1, HPAC and H727 cells. [1]
In vivo	METHODS: A cell line-derived xenograft model was established, and mice were randomly assigned according to tumor size (n = 7-8 mice per treatment group) and treated with BI-2493 (10-90 mg/kg, orally twice daily) . RESULTS BI-2493 attenuated tumor growth in xenograft model mice. [1]

Chemical Properties

Molecular Weight	461.58
Formula	C₂₄H₂₇N₇OS
Cas No.	2937344-16-4
Smiles	C(#N)C=1C=2[C@@]3(C4=C(C(=NO4)C5=NC(=NC=C5)N6[C@@H](C)CNCC6)CCC3)CCCC2SC1N
Relative Density.	1.41 g/cm3 at 20℃ (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (129.99 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1665 mL	10.8324 mL	21.6647 mL	108.3236 mL
5 mM	0.4333 mL	2.1665 mL	4.3329 mL	21.6647 mL
10 mM	0.2166 mL	1.0832 mL	2.1665 mL	10.8324 mL
20 mM	0.1083 mL	0.5416 mL	1.0832 mL	5.4162 mL
50 mM	0.0433 mL	0.2166 mL	0.4333 mL	2.1665 mL
100 mM	0.0217 mL	0.1083 mL	0.2166 mL	1.0832 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc