Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.BI-2493 exhibits antitumor activity and inhibits tumor cell growth and can be used in the study of cancerous diseases.BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 630.00 | |
5 mg | In stock | $ 1,550.00 | |
10 mg | In stock | $ 2,480.00 | |
25 mg | In stock | $ 3,680.00 | |
50 mg | In stock | $ 4,900.00 | |
100 mg | In stock | $ 6,630.00 |
Description | BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.BI-2493 exhibits antitumor activity and inhibits tumor cell growth and can be used in the study of cancerous diseases.BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865. |
In vitro | BI-2493 inhibits the proliferation with IC50 values < 140 nM in Ba/F3 cell lines made dependent on KRAS by transfection of different mutant KRAS oncogenes (e.g., KRAS G12C, KRAS G12D, KRAS G12V)[1]. |
In vivo | BI-2493 (90 mg/kg; gavage) attenuats tumour growth in mice bearing KRAS G12C, G12D, G12V and A146V mutant models, without causing apparent toxicity to the mice[1]. |
Molecular Weight | 461.58 |
Formula | C24H27N7OS |
CAS No. | 2937344-16-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (129.99 mM), Sonication and heating are recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BI-2493 2937344-16-4 GPCR/G Protein MAPK Ras BI2493 BI 2493 inhibitor inhibit