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BI-2493

🥰Excellent
Catalog No. T72061Cas No. 2937344-16-4

BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.BI-2493 exhibits antitumor activity and inhibits tumor cell growth and can be used in the study of cancerous diseases.BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.

BI-2493

BI-2493

🥰Excellent
Purity: 99.88%
Catalog No. T72061Cas No. 2937344-16-4
BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.BI-2493 exhibits antitumor activity and inhibits tumor cell growth and can be used in the study of cancerous diseases.BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$629In StockIn Stock
5 mg$1,550In StockIn Stock
10 mg$2,230In StockIn Stock
25 mg$2,980In StockIn Stock
50 mg$3,970In StockIn Stock
1 mL x 10 mM (in DMSO)$1,720In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.88%
ee:100%
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COA CSFC HNMR LCMS

Product Introduction

Bioactivity
Description
BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.BI-2493 exhibits antitumor activity and inhibits tumor cell growth and can be used in the study of cancerous diseases.BI-2493 is a highly selective pan-KRAS inhibitor and structural analog of BI-2865.
Targets&IC50
HSKTC cells:130.0 nM, SNU-245 cells:136.1 nM, KRAS (G12V):11 nM, KRas (G12C):3 nM, HuG1-N cells:59.1 nM, KRAS (G12D):2 nM, SAS cells:413.4 nM
In vitro
METHODS: ASPC1, HPAC and H727 cells were treated with BI-2493 (Log (1-4nM)), and cell viability was detected after 72 hours.
RESULTS BI-2493 inhibited the growth of ASPC1, HPAC and H727 cells. [1]
In vivo
METHODS: A cell line-derived xenograft model was established, and mice were randomly assigned according to tumor size (n = 7-8 mice per treatment group) and treated with BI-2493 (10-90 mg/kg, orally twice daily) .
RESULTS BI-2493 attenuated tumor growth in xenograft model mice. [1]
Chemical Properties
Molecular Weight461.58
FormulaC24H27N7OS
Cas No.2937344-16-4
SmilesC(#N)C=1C=2[C@@]3(C4=C(C(=NO4)C5=NC(=NC=C5)N6[C@@H](C)CNCC6)CCC3)CCCC2SC1N
Relative Density.1.41 g/cm3 at 20℃ (Predicted)
ColorYellow
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (129.99 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1665 mL10.8324 mL21.6647 mL108.3236 mL
5 mM0.4333 mL2.1665 mL4.3329 mL21.6647 mL
10 mM0.2166 mL1.0832 mL2.1665 mL10.8324 mL
20 mM0.1083 mL0.5416 mL1.0832 mL5.4162 mL
50 mM0.0433 mL0.2166 mL0.4333 mL2.1665 mL
100 mM0.0217 mL0.1083 mL0.2166 mL1.0832 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

KRASBI-2493BI2493BI 2493
Related Tags: buy BI-2493 | purchase BI-2493 | BI-2493 cost | order BI-2493 | BI-2493 chemical structure | BI-2493 in vivo | BI-2493 in vitro | BI-2493 formula | BI-2493 molecular weight
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