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MC-1-F2

🥰Excellent
Catalog No. T69659Cas No. 2376894-10-7

MC-1-F2 is a direct FOXC2 inhibitor with anticancer activity, inhibits cancer stem cell (CSC) characteristics, and reduces the invasive ability of castration-resistant prostate cancer (CRPC) cell lines. MC-1-F2 can be used to study prostate cancer.

MC-1-F2

MC-1-F2

🥰Excellent
Purity: 98.44%
Catalog No. T69659Cas No. 2376894-10-7
MC-1-F2 is a direct FOXC2 inhibitor with anticancer activity, inhibits cancer stem cell (CSC) characteristics, and reduces the invasive ability of castration-resistant prostate cancer (CRPC) cell lines. MC-1-F2 can be used to study prostate cancer.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$256In StockIn Stock
5 mg$629In StockIn Stock
10 mg$892In StockIn Stock
25 mg$1,480In StockIn Stock
50 mg$1,970In StockIn Stock
100 mg$2,480In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:98.44%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
MC-1-F2 is a direct FOXC2 inhibitor with anticancer activity, inhibits cancer stem cell (CSC) characteristics, and reduces the invasive ability of castration-resistant prostate cancer (CRPC) cell lines. MC-1-F2 can be used to study prostate cancer.
In vitro
In PC3 or DU145 cell lines after treatment with DMSO (D), MC-1-F2 (F2, 20 µM) or MC-C2 (C, 20 µM) for 48 hours. A clear decrease in FOXC2 protein level upon 48-hour treatment with MC-1-F2. [1]
Chemical Properties
Molecular Weight746.87
FormulaC37H46N16O2
Cas No.2376894-10-7
SmilesN=C(N)NCCCCNC1=NC(=NC(=N1)N2CCN(C=3N=C(N=C(N3)NC4=CC=C(C=C4)N5CCOCC5)N)CC2)NC6=CC=C(OC=7C=CC=CC7)C=C6
ColorYellow
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (107.11 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (4.42 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.3389 mL6.6946 mL13.3892 mL66.9461 mL
5 mM0.2678 mL1.3389 mL2.6778 mL13.3892 mL
10 mM0.1339 mL0.6695 mL1.3389 mL6.6946 mL
20 mM0.0669 mL0.3347 mL0.6695 mL3.3473 mL
50 mM0.0268 mL0.1339 mL0.2678 mL1.3389 mL
100 mM0.0134 mL0.0669 mL0.1339 mL0.6695 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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