Ac-RYYRWK-NH2 TFA

Name: Ac-RYYRWK-NH2 TFA
Brand: TargetMol
SKU: T40510
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Catalog No. T40510Cas No. 408305-09-9

Alias Ac-RYYRWK-NH2 TFA

Ac-RYYRWK-NH2 is a highly effective and specific partial agonist for the nociceptin receptor (NOP). It demonstrates a remarkable affinity for rat cortical membranes ORL1, with [3H]Ac-RYYRWK-NH2 exhibiting a Kd value of 0.071 nM. However, it shows negligible affinity towards μ-, κ-, or δ-opioid receptors.

Ac-RYYRWK-NH2 TFA

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Catalog No. T40510Alias Ac-RYYRWK-NH2 TFACas No. 408305-09-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
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500 mg	Inquiry	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Ac-RYYRWK-NH2 is a highly effective and specific partial agonist for the nociceptin receptor (NOP). It demonstrates a remarkable affinity for rat cortical membranes ORL1, with [3H]Ac-RYYRWK-NH2 exhibiting a Kd value of 0.071 nM. However, it shows negligible affinity towards μ-, κ-, or δ-opioid receptors.
In vitro	Binding studies with [3H]ac-RYYRWK-NH2 on rat cortical membranes identified a single high-affinity binding site (Kd = 0.071 nM). Furthermore, Naloxone benzoylhydrazone competitively inhibited [3H]ac-RYYRWK-NH2 binding to rat cortical membranes (Ki = 104 nM) and to human ORL1 receptors (Ki = 136 nM). It also displaced [125I]Tyr14-NC-OH binding to ORL1 receptors with a Ki of 37 nM, indicating specificity as it showed no affinity for μ-, κ-, or δ-opioid receptors.
Synonyms	Ac-RYYRWK-NH2 TFA

Chemical Properties

Molecular Weight	1126.21
Formula	C₅₁H₇₀F₃N₁₅O₁₁
Cas No.	408305-09-9
Smiles	OC(=O)C(F)(F)F.CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(N)=O
Sequence	Ac-Arg-Tyr-Tyr-Arg-Trp-Lys-NH2.TFA
Sequence Short	RYYRWK

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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