Shopping Cart

Your shopping cart is currently empty

BAY1238097

Name: BAY1238097
Brand: TargetMol
SKU: T12660L
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Catalog No. T12660LCas No. 1564268-08-1

BAY1238097, a potent and selective bromodomain and extra-terminal motif (BET) inhibitor with anticancer activity, exhibits strong antiproliferative effects in AML (Acute Myeloid Leukemia) and MM (Multiple Myeloma) models. BAY1238097 is useful for studying advanced refractory malignancies.

BAY1238097

😃Good

Purity: 98.79%

Catalog No. T12660LCas No. 1564268-08-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$47	-	In Stock
5 mg	$108	-	In Stock
10 mg	$185	-	In Stock
25 mg	$395	-	In Stock
50 mg	$689	-	In Stock
100 mg	$1,160	-	In Stock
200 mg	$1,560	-	In Stock
1 mL x 10 mM (in DMSO)	$122	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.79%

ee:99.86%

Appearance:Solid

Color:White to Yellow

Resource Download

COA CSFC HNMR LCMS ORP

Product Introduction

Bioactivity

Description	BAY1238097, a potent and selective bromodomain and extra-terminal motif (BET) inhibitor with anticancer activity, exhibits strong antiproliferative effects in AML (Acute Myeloid Leukemia) and MM (Multiple Myeloma) models. BAY1238097 is useful for studying advanced refractory malignancies.
Targets&IC50	H4:2430 nM, BRD3(BRD2):609 nM, BET:< 100 nM (TR-FRET assay), BRD4:63 nM
In vitro	BAY 1238097 exhibits potent inhibitory activity (IC50 < 100 nM) in a TR-FRET assay utilizing BET BRD4 bromodomain 1 and an acetylated peptide derived from histone H4. In the NanoBRET assay, it inhibits the interaction between BRD4 (IC50=63 nM), BRD3, or BRD2 (IC50=609 nM), and H4 (IC50=2430 nM)[2]. BAY 1238097 demonstrates in vitro anti-tumor activity in lymphoma models. It influences the gene expression of GCB DLBCL cells. At the gene level, top downregulated genes include BTK, CCDC86, CCND2, CD19, CD27, FAIM, FCMR (FAIM3), IL7R, IRAK1, MAPK13, MYB, MYC, PDE4B, TNFRSF13B, TNFRSF17. In addition to histone-coding genes, upregulated genes include CCL5, CDKN2C, CD69, JUN, and MKNK2[1].
In vivo	BAY 1238097 demonstrates robust efficacy in AML and MM models. It exhibits in vivo anti-tumor activity in lymphoma models[1][2]. BAY 1238097 is well tolerated at doses of 10-15 mg/kg administered daily over 9-14 days in various disease models, with no apparent toxicity[1][2].

Chemical Properties

Molecular Weight	451.56
Formula	C₂₅H₃₃N₅O₃
Cas No.	1564268-08-1
Smiles	CNC(=O)N1N=C(c2ccc(cc2)N2CCN(C)CC2)c2cc(OC)c(OC)cc2C[C@@H]1C
Relative Density.	1.22 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (221.45 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (8.86 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2145 mL	11.0727 mL	22.1455 mL	110.7273 mL
5 mM	0.4429 mL	2.2145 mL	4.4291 mL	22.1455 mL
10 mM	0.2215 mL	1.1073 mL	2.2145 mL	11.0727 mL
20 mM	0.1107 mL	0.5536 mL	1.1073 mL	5.5364 mL
50 mM	0.0443 mL	0.2215 mL	0.4429 mL	2.2145 mL
100 mM	0.0221 mL	0.1107 mL	0.2215 mL	1.1073 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc