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Niraparib tosylate monohyrate

Name: Niraparib tosylate monohyrate
Brand: TargetMol
SKU: T9497
Price: 55 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9497Cas No. 1613220-15-7

Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. The PARP family of proteins detect and repair single strand DNA breaks by the base-excision repair (BER) pathway.

Niraparib tosylate monohyrate

🥰Excellent

Purity: 98.41%

Catalog No. T9497Cas No. 1613220-15-7

Pack Size	Price	Availability
5 mg	$55	In Stock
10 mg	$79	In Stock
25 mg	$119	In Stock
50 mg	$147	In Stock
100 mg	$228	In Stock
200 mg	$343	In Stock
500 mg	$573	In Stock
1 mL x 10 mM (in DMSO)	$70	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.41%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. The PARP family of proteins detect and repair single strand DNA breaks by the base-excision repair (BER) pathway.
Targets&IC50	PARP4:330 nM, PARP1:3.8 nM, tankyrase 1:570 nM, PARP3:1300 nM, PARP2:2.1 nM

Chemical Properties

Molecular Weight	510.61
Formula	C₂₆H₃₀N₄O₅S
Cas No.	1613220-15-7
Smiles	CC1=CC=C(S(=O)(O)=O)C=C1.O=C(N)C(C2=N3)=CC=CC2=CN3C(C=C4)=CC=C4[C@@H]5CCCNC5.O
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 1 mg/mL (1.96 mM), Sonication is recommended.

DMSO: 70 mg/mL (137.09 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.92 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9584 mL	9.7922 mL	19.5844 mL	97.9221 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.3917 mL	1.9584 mL	3.9169 mL	19.5844 mL
10 mM	0.1958 mL	0.9792 mL	1.9584 mL	9.7922 mL
20 mM	0.0979 mL	0.4896 mL	0.9792 mL	4.8961 mL
50 mM	0.0392 mL	0.1958 mL	0.3917 mL	1.9584 mL
100 mM	0.0196 mL	0.0979 mL	0.1958 mL	0.9792 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc