Shopping Cart

Your shopping cart is currently empty

PI3Kδ-IN-1

Name: PI3Kδ-IN-1
Brand: TargetMol
SKU: T12462
Price: 58 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T12462Cas No. 1911564-39-0

PI3Kδ-IN-1 is an efficacious PI3Kδ inhibitor (IC50 of 1.7 nM).

PI3Kδ-IN-1

🥰Excellent

Purity: 99.85%

Catalog No. T12462Cas No. 1911564-39-0

PI3Kδ-IN-1 is an efficacious PI3Kδ inhibitor (IC50 of 1.7 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$58	-	In Stock
5 mg	$148	-	In Stock
10 mg	$238	-	In Stock
25 mg	$397	-	In Stock
50 mg	$567	-	In Stock
100 mg	$768	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.85%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	PI3Kδ-IN-1 is an efficacious PI3Kδ inhibitor (IC50 of 1.7 nM).
Targets&IC50	PI3Kδ:1.7 nM
In vitro	PI3Kδ-IN-1 has an improved human/rodent in vitro stability correlation and a good permeability profile[1].
In vivo	PI3Kδ-IN-1 shows greater than 50% suppression of paw swelling in mice. PI3Kδ-IN-1 has an EC50 of 10 nM at 24 h (ED50 of ∼1.25 mg/kg) in mice[1].

Chemical Properties

Molecular Weight	471.44
Formula	C₂₂H₂₀F₃N₇O₂
Cas No.	1911564-39-0
Smiles	CC(=O)N1CCN(C(=O)C1(C)C)c1cc(ccc1C#N)-c1cc(c2c(N)ncnn12)C(F)(F)F
Relative Density.	1.47 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 18 mg/mL (38.18 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.1212 mL	10.6058 mL	21.2116 mL	106.0580 mL
5 mM	0.4242 mL	2.1212 mL	4.2423 mL	21.2116 mL
10 mM	0.2121 mL	1.0606 mL	2.1212 mL	10.6058 mL
20 mM	0.1061 mL	0.5303 mL	1.0606 mL	5.3029 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc