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Artemisone

Name: Artemisone
Brand: TargetMol
SKU: T14324
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T14324Cas No. 255730-18-8

Alias BAY 44-9585, Artemifone

Artemisone (BAY 44-9585) is a potent and semi-synthetic antimalarial, inhibits P. falciparum strains (IC50: 0.83 nM). It also is a potent inhibitor of human CMV.

Artemisone

🥰Excellent

Purity: 99.9%

Catalog No. T14324Alias BAY 44-9585, ArtemifoneCas No. 255730-18-8

Artemisone (BAY 44-9585) is a potent and semi-synthetic antimalarial, inhibits P. falciparum strains (IC50: 0.83 nM). It also is a potent inhibitor of human CMV.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$47	In Stock	In Stock
5 mg	$103	In Stock	In Stock
10 mg	$163	In Stock	In Stock
25 mg	$271	In Stock	In Stock
50 mg	$382	In Stock	In Stock
100 mg	$515	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$113	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.9%

ee:100%

Appearance:Solid

Color:White

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COA HNMR CSFC LCMS

Product Introduction

Bioactivity

Description	Artemisone (BAY 44-9585) is a potent and semi-synthetic antimalarial, inhibits P. falciparum strains (IC50: 0.83 nM). It also is a potent inhibitor of human CMV.
Targets&IC50	P. falciparum:0.83 nM
In vitro	Artemisone inhibits 3D7 and K1 P. falciparum with IC50 values of 0.88±0.59 nM and 1.23±0.64 nM, respectively.
In vivo	Artemisone, when administered subcutaneously at doses of 3, 1, 0.3, and 0.1 mg/kg in conjunction with other antimalarials, demonstrates an enhanced effectiveness against the chloroquine-resistant P. yoelii NS strain[1]. Moreover, it is effective at inhibiting parasitemia in the P. berghei NY susceptible strain, achieving an ED50 of 9.62 mg/kg through the subcutaneous route and 11.67 mg/kg when given orally[1].
Synonyms	BAY 44-9585, Artemifone

Chemical Properties

Molecular Weight	401.52
Formula	C₁₉H₃₁NO₆S
Cas No.	255730-18-8
Smiles	[H][C@@]12CC[C@@H](C)[C@]3([H])CC[C@@]4(C)OO[C@@]13[C@]([H])(O[C@H]([C@@H]2C)N1CCS(=O)(=O)CC1)O4
Relative Density.	1.33 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 130 mg/mL (323.77 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.96 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4905 mL	12.4527 mL	24.9054 mL	124.5268 mL
5 mM	0.4981 mL	2.4905 mL	4.9811 mL	24.9054 mL
10 mM	0.2491 mL	1.2453 mL	2.4905 mL	12.4527 mL
20 mM	0.1245 mL	0.6226 mL	1.2453 mL	6.2263 mL
50 mM	0.0498 mL	0.2491 mL	0.4981 mL	2.4905 mL
100 mM	0.0249 mL	0.1245 mL	0.2491 mL	1.2453 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc