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Anti-KIR2DL1 Antibody (4W251)
😃Good
Catalog No. TMAY-02503
Alias XXbac-BPG184J6.7, XXbac-BCX195L8.1, p58.1, NKAT-1, NKAT1, NKAT, KIR-K64, KIR221, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1, CD158A
Anti-KIR2DL1 Antibody (4W251) is a Rabbit antibody targeting KIR2DL1. Anti-KIR2DL1 Antibody (4W251) can be used in FCM.
Anti-KIR2DL1 Antibody (4W251)
Anti-KIR2DL1 Antibody (4W251)
😃Good
Catalog No. TMAY-02503Alias XXbac-BPG184J6.7, XXbac-BCX195L8.1, p58.1, NKAT-1, NKAT1, NKAT, KIR-K64, KIR221, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1, CD158A
Anti-KIR2DL1 Antibody (4W251) is a Rabbit antibody targeting KIR2DL1. Anti-KIR2DL1 Antibody (4W251) can be used in FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
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Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-KIR2DL1 Antibody (4W251) is a Rabbit antibody targeting KIR2DL1. Anti-KIR2DL1 Antibody (4W251) can be used in FCM. |
| Alias | XXbac-BPG184J6.7, XXbac-BCX195L8.1, p58.1, NKAT-1, NKAT1, NKAT, KIR-K64, KIR221, killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1, CD158A |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 4W251 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human KIR2DL1(CD158a) expression on human whole blood lymphocytes. Cells were stained with purified anti-Human KIR2DL1(CD158a), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes. |
| Application | FCM |
| Recommended Dose | FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human KIR2DL1 / CD158a (rh KIR2DL1 / CD158a; TMPY-02629; NP_055033.2; Met1-His245). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Killer cell immunoglobulin-like receptor 2DL1 or KIR2DL1 is an inhibitory Natural Killer cell immunoglobulin-like receptor with two extracellular immunoglobulin domains. KIR2DL1 is a member of the Killer cell immunoglobulin-like receptor family whose members are classified by the number of the extracellular immunoglobulin domains and the length of the cytoplasm domain. KIR2DL1 is a transmembrane glycoprotein expressed by natural killer cells and subsets of T cells. KIR2DL1 down-regulates the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. It has been reported that the KIR2DL1 is bound to its class I MHC ligand, HLA-Cw4. The KIR2DL1-HLA-Cw4 interface exhibits charge and shape complementarity. Specificity is mediated by a pocket in KIR2DL1 that hosts the Lys80 residue of HLA-Cw4. Many residues conserved in HLA-C and KIR2DL receptors make different interactions in KIR2DL1-HLA-Cw4 and a previously reported KIR2DL2-HLA-Cw3 complex. A dimeric aggregate of KIR-HLA-C complexes was observed in one KIR2DL1-HLA-Cw4 crystal. |
| Conjucates | Unconjugated |
| Others Formats | APC/PerCP/FITC/PE |
| Antibody Types Available | 5 |
| Immunogen | Recombinant Human KIR2DL1 / CD158a Protein (TMPY-02629) |
| Antigen Species | Human |
| Biology Area | ITIM/ITAM Immunoreceptors and Related Molecules |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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