Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sirt1/2-IN-3 (compound PS9) serves as a dual inhibitor of SIRT1/2, exhibiting IC50 values of 1.4 μM (SIRT1) and 2.0 μM (SIRT2), respectively. This compound effectively inhibits p53 deacetylation while simultaneously elevating p53 and α-tubulin acetylation levels. Additionally, Sirt1/2-IN-3 promotes apoptosis and exhibits antiproliferative effects on human leukemia cell lines [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | Inquiry | |
50 mg | Inquiry | Inquiry |
Description | Sirt1/2-IN-3 (compound PS9) serves as a dual inhibitor of SIRT1/2, exhibiting IC50 values of 1.4 μM (SIRT1) and 2.0 μM (SIRT2), respectively. This compound effectively inhibits p53 deacetylation while simultaneously elevating p53 and α-tubulin acetylation levels. Additionally, Sirt1/2-IN-3 promotes apoptosis and exhibits antiproliferative effects on human leukemia cell lines [1]. |
In vitro | Sirt1/2-IN-3 (compound hsa55) at 5 μM for 48 hours induces apoptosis in various tumor cells, with IC50 values of 6.5 μM (MV4-11), 9.2 μM (MOLM-13), 27.2 μM (THP1), and 17.4 μM (Jurkat) [1]. At 100 μM for 30 minutes, Sirt1/2-IN-3 reduces the thermal stability of SIRT1 and SIRT2 proteins across different temperatures, and at concentrations of 25 μM and 30 μM over 24 hours, it increases the levels of acetylated p53 and α-tubulin in MOLM-13 cells [1]. |
Molecular Weight | 363.82 |
Formula | C17H14ClNO4S |
CAS No. | 301313-42-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Sirt1/2-IN-3 301313-42-8 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin inhibitor inhibit