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SD-1029

Name: SD-1029
Brand: TargetMol
SKU: T24774
Rating: 4.5 (1 reviews)

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Catalog No. T24774Cas No. 118372-34-2

Alias SD1029, SD 1029, NSC-371488, NSC371488, NSC 371488

SD-1029 is a JAK2 inhibitor and a novel Stat3 activation inhibitor that inhibits Stat3 phosphorylation and JAK-STAT signaling.

SD-1029

😃Good

Catalog No. T24774Alias SD1029, SD 1029, NSC-371488, NSC371488, NSC 371488Cas No. 118372-34-2

SD-1029 is a JAK2 inhibitor and a novel Stat3 activation inhibitor that inhibits Stat3 phosphorylation and JAK-STAT signaling.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$123	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	SD-1029 is a JAK2 inhibitor and a novel Stat3 activation inhibitor that inhibits Stat3 phosphorylation and JAK-STAT signaling.
In vitro	SD-1029 inhibits EGFP-Stat3 nuclear translocation in BHK-21 and U-2OS cells and suppresses p-Stat3 levels in human breast and ovarian cancer cell lines including cell growth and induces apoptosis in OVCAR8TR ovarian cancer cells. [1] SD-1029 inhibits JAK2 phosphorylation and the phosphorylation of STAT1 and STAT3. SD-1029 strongly inhibits Tyk2 phosphorylation, implicating both JAK2 and Tyk2 as upstream requirements for IL-23-induced IL-23R expression. [2]
Synonyms	SD1029, SD 1029, NSC-371488, NSC371488, NSC 371488

Chemical Properties

Molecular Weight	639.25
Formula	C₂₅H₃₂Br₂Cl₂N₂O₃
Cas No.	118372-34-2
Smiles	O=C1C2=C(CCC1CN(C)C)OC3=C(C2C4=CC=C(C(Cl)=C4)Cl)C(C(CC3)CN(C)C)=O.Br.Br
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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