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ACA-28
🥰Excellent
Catalog No. T60821Cas No. 948044-25-5
Alias G1T28
ACA-28 is an ERK MAPK signalling modulator that induces apoptosis in melanoma cells by overexpressing ERK. Its IC₅₀ values for melanoma cells (SK-MEL-28) and normal melanocytes (NHEM) are 5.3 and 10.1 μM respectively.
ACA-28
🥰Excellent
Purity: 98.73%
Catalog No. T60821Alias G1T28Cas No. 948044-25-5
ACA-28 is an ERK MAPK signalling modulator that induces apoptosis in melanoma cells by overexpressing ERK. Its IC₅₀ values for melanoma cells (SK-MEL-28) and normal melanocytes (NHEM) are 5.3 and 10.1 μM respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $105 | In Stock | |
| 5 mg | $259 | In Stock | |
| 10 mg | $418 | In Stock | |
| 25 mg | $843 | In Stock | |
| 50 mg | $1,290 | In Stock | |
| 100 mg | $1,990 | In Stock | |
| 200 mg | $2,680 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $286 | In Stock |
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Purity:98.73%
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Product Introduction
Bioactivity
Chemical Properties
| Description | ACA-28 is an ERK MAPK signalling modulator that induces apoptosis in melanoma cells by overexpressing ERK. Its IC₅₀ values for melanoma cells (SK-MEL-28) and normal melanocytes (NHEM) are 5.3 and 10.1 μM respectively. |
| Targets&IC50 | NHEM:10.1 μM, SK-MEL-28 cells:5.3 μM |
| In vitro | Methods: A4-15 cells were treated with ACA-28 (0-10μM), and cell proliferation and related protein expression levels were measured using WST-8 and Western blot. Result: ACA-28 selectively downregulated DUSP6 and inhibited the growth of A4-15 cells. [2] |
| Synonyms | G1T28 |
| Molecular Weight | 316.31 |
| Formula | C17H16O6 |
| Cas No. | 948044-25-5 |
| Smiles | C(OC(OC)=O)(C1=CC=C(OC(OC)=O)C=C1)C2=CC=CC=C2 |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (252.92 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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