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CDK9-IN-12

Name: CDK9-IN-12
Brand: TargetMol
SKU: T39354
Price: 58 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39354Cas No. 1942843-54-0

CDK9-IN-12 is a highly selective CDK9 inhibitor, which is commonly used in leukemia research to regulate oncogene expression, inhibit oncogenic proliferation, and induce apoptosis by targeting CDK9-dependent transcription processes.

CDK9-IN-12

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Purity: 98.93%

Catalog No. T39354Cas No. 1942843-54-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$58	In Stock	In Stock
5 mg	$139	In Stock	In Stock
10 mg	$222	In Stock	In Stock
25 mg	$463	In Stock	In Stock
50 mg	$745	In Stock	In Stock
100 mg	$987	-	In Stock
200 mg	$1,370	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.93%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	CDK9-IN-12 is a highly selective CDK9 inhibitor, which is commonly used in leukemia research to regulate oncogene expression, inhibit oncogenic proliferation, and induce apoptosis by targeting CDK9-dependent transcription processes.
Targets&IC50	CDK9-CyclinT1:5.41 nM
In vitro	CDK9-IN-12 has an inhibitory effect on the following cells: Mino, Z-138, JeKo-1, Raji, OCI-Ly-10, TMD8, MM.1S, RPMI-8226, Kasumi-1, HL-60, CCRF-CEM, MV-4-11 cells with IC50 values of 8.4, 46, 46, 37, 3.2, 46, 1.5, 5.4, 21, 44, 2.1, 1.6 nM, respectively. [1]
In vivo	Methods: CDK9-IN-12 (7.5 mg/kg, 0.5% CMC-Na, gavage, 21 days) was used to treat MV-4-11 cell tumor xenograft model mice. First, PK experiments were performed in mice. Second, the diameter of the transplanted tumor and the weight of the mice were measured twice a week to evaluate the in vivo anticancer effect. Results: CDK9-IN-12 has a long half-life (t1/2 = 8.02 h) and acceptable bioavailability (F = 33.7%). In addition, CDK9-IN-12 can significantly inhibit tumor progression, with a T/C value of 27.80%. [1]

Chemical Properties

Molecular Weight	378.86
Formula	C₂₁H₁₉ClN₄O
Cas No.	1942843-54-0
Smiles	ClC1=C(C=2C=C3C(=CC2)NN=C3C)C=C(N[C@@H](CO)C4=CC=CC=C4)C=N1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (211.16 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (8.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6395 mL	13.1975 mL	26.3950 mL	131.9749 mL
5 mM	0.5279 mL	2.6395 mL	5.2790 mL	26.3950 mL
10 mM	0.2639 mL	1.3197 mL	2.6395 mL	13.1975 mL
20 mM	0.1320 mL	0.6599 mL	1.3197 mL	6.5987 mL
50 mM	0.0528 mL	0.2639 mL	0.5279 mL	2.6395 mL
100 mM	0.0264 mL	0.1320 mL	0.2639 mL	1.3197 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc