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DiMNF (3',4'-Dimethoxy-αNF) is a selective and potent modulator of the aryl hydrocarbon receptor (AHR) and an AHR ligand with anti-inflammatory activity that inhibits cytokine-mediated induction of complement factor genes.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $37 | In Stock | In Stock | |
| 5 mg | $85 | In Stock | In Stock | |
| 10 mg | $133 | In Stock | In Stock | |
| 25 mg | $218 | In Stock | In Stock | |
| 50 mg | $325 | In Stock | In Stock | |
| 100 mg | $483 | In Stock | In Stock | |
| 200 mg | $691 | - | In Stock |
| Description | DiMNF (3',4'-Dimethoxy-αNF) is a selective and potent modulator of the aryl hydrocarbon receptor (AHR) and an AHR ligand with anti-inflammatory activity that inhibits cytokine-mediated induction of complement factor genes. |
| Targets&IC50 | AhR:21 nM |
| In vitro | DiMNF is a modulator that selectively acts on the aromatic hydrocarbon receptor (AHR). As a competitive AHR ligand, DiMNF has an IC50 = 21 nM and exhibits significant antagonistic activity, with DiMNF showing a unique binding mode in the ligand binding site of the AHR. DiMNF effectively inhibited cytokine-induced inflammatory gene expression at a concentration of 10 μM for 1 hour. [1] |
| Synonyms | 3',4'-Dimethoxy-αNF |
| Molecular Weight | 332.35 |
| Formula | C21H16O4 |
| Cas No. | 14756-24-2 |
| Smiles | O=C1C=C(OC2=C1C=CC=3C=CC=CC32)C=4C=CC(OC)=C(OC)C4 |
| Relative Density. | 1.31g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | DMSO: 1 mg/mL (3.01 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
| |||||||||||
Dissolve 2 mg of the compound in 100 μL DMSO
to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO
stock solution to 400 μL PEG300
and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O
and mix thoroughly until a homogeneous solution is obtained.
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