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DiMNF
🥰Excellent
Catalog No. T22725Cas No. 14756-24-2
Alias 3',4'-Dimethoxy-αNF
DiMNF (3',4'-Dimethoxy-αNF) is a selective and potent modulator of the aryl hydrocarbon receptor (AHR) and an AHR ligand with anti-inflammatory activity that inhibits cytokine-mediated induction of complement factor genes.
DiMNF
🥰Excellent
Purity: 97.60%
Catalog No. T22725Alias 3',4'-Dimethoxy-αNFCas No. 14756-24-2
DiMNF (3',4'-Dimethoxy-αNF) is a selective and potent modulator of the aryl hydrocarbon receptor (AHR) and an AHR ligand with anti-inflammatory activity that inhibits cytokine-mediated induction of complement factor genes.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $37 | In Stock | |
| 5 mg | $85 | In Stock | |
| 10 mg | $133 | In Stock | |
| 25 mg | $218 | In Stock | |
| 50 mg | $325 | In Stock | |
| 100 mg | $483 | In Stock | |
| 200 mg | $691 | In Stock |
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:97.60%
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Product Introduction
Bioactivity
Chemical Properties
| Description | DiMNF (3',4'-Dimethoxy-αNF) is a selective and potent modulator of the aryl hydrocarbon receptor (AHR) and an AHR ligand with anti-inflammatory activity that inhibits cytokine-mediated induction of complement factor genes. |
| Targets&IC50 | AhR:21 nM |
| In vitro | DiMNF is a modulator that selectively acts on the aromatic hydrocarbon receptor (AHR). As a competitive AHR ligand, DiMNF has an IC50 = 21 nM and exhibits significant antagonistic activity, with DiMNF showing a unique binding mode in the ligand binding site of the AHR. DiMNF effectively inhibited cytokine-induced inflammatory gene expression at a concentration of 10 μM for 1 hour. [1] |
| Alias | 3',4'-Dimethoxy-αNF |
| Molecular Weight | 332.35 |
| Formula | C21H16O4 |
| Cas No. | 14756-24-2 |
| Smiles | O=C1C=C(OC2=C1C=CC=3C=CC=CC32)C=4C=CC(OC)=C(OC)C4 |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | DMSO: 1 mg/mL (3.01 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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