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P-gp

P-glycoprotein (P-gp) is a plasma membrane protein which acts as a localized drug transport mechanism, actively exporting drugs out of the cell. The effects of P-gp on the distribution, metabolism and excretion of drugs — including protease inhibitors — in the body is great.

Valspodar
T17216121584-18-7
Valspodar (PSC 833), a specific P-glycoprotein inhibitor and MDR regulator, is commonly used as a chemical sensitizer in the study of advanced epithelial ovarian cancer.
  • $289
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Elacridar
T2657143664-11-3
Elacridar (GG918) is a potent inhibitor of P-glycoprotein and BCRP.
  • $35
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Zosuquidar trihydrochloride
T6018167465-36-3
Zosuquidar trihydrochloride (LY-335979 trihydrochloride) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM. Phase 3.
  • $30
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Verapamil
T2065652-53-9
Verapamil (CP-16533-1) is a calcium channel blocker and an orally active and effective inhibitor of P-gp. Verapamil inhibits CYP3A4 and can be used in studies about the treatment of high blood pressure, heart arrhythmias, and angina research.
  • $30
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Tariquidar
T6287206873-63-4
Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines.
  • $45
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Solamargine
T403420311-51-7
Solamargine (δ-Solanigrine) is a major steroidal alkaloid glycoside extracted from a traditional Chinese medicine herb, Solanum nigrum L. (SNL); has been shown to inhibit growth and induce apoptosis of various cancer cells.
  • $54
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Cinobufotalin
T4A23991108-68-5
Cinobufotalin is a main cardiac toxin in toad, it is a novel anti-HCC agent, it induces growth inhibition and apoptosis in cultured HCC cells through ceramide production. Cinobufotalin is also an effective reversal agent for the multidrug resistance of tu
  • $44
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Paris saponin VII
T408568124-04-9
Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.
  • $46
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Trifluoperazine
T8389117-89-5
Trifluoperazine (trifluoroperazine) is a Dopamine D2 receptor inhibitor(IC50 : 1.2 nM), and Treatment of schizophrenia.
  • $41
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Risperidone
T0351106266-06-2
Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.
  • $43
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Larotaxel
T15713156294-36-9
Larotaxel (XRP9881) is a taxane analogue with anticancer activity that promotes tubulin assembly and stabilizes microtubules, inducing apoptosis. It crosses the blood-brain barrier and has a higher affinity for Docetaxel than P-glycoprotein 1, making it useful for studying breast and bladder cancer.
  • $123
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Atazanavir sulfate
T0100229975-97-7
Atazanavir sulfate (BMS-232632 sulfate) is an azapeptide and HIV-protease inhibitor used in the treatment of HIV infections and AIDS in combination with other anti-HIV agents.
  • $39
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Zosuquidar
T6018L167354-41-8
Zosuquidar (RS 33295-198) is a potent P-glycoprotein inhibitor with antitumor activity, inhibits tumor growth, significantly inhibits PD-L1 expression by triggering its autophagic degradation, and is used in the study of acute myeloid leukemia.
  • $1,298
1-2 weeks
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Sinapine
T2S120018696-26-9
1. Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. 2. Sinapine has antioxidant and radio-protective activities.
  • $72
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Glibenclamide
T163410238-21-8
Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
  • $45
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Encequidar
T8426849675-66-7
Encequidar (HM30181A) is a potent and selective P-glycoprotein inhibitor.
  • $41
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Atazanavir
T0100L198904-31-3
Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.
  • $39
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Isosinensetin
T2S022317290-70-9
1. Isosinensetin (6-Demethoxynobiletin) shows antioxidant and HIV-1 protease inhibiting activities.
  • $60
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coniferyl ferulate
T3S001263644-62-2
Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis. It shows strong inhibition of human placental GST (IC50: 0.3 μM). It also reverses multidrug resistance and downregulates P-glycoprotein.
  • $80
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Taxol C
TN5118153415-45-3
Taxol C can reduce interaction with the P-glycoprotein transporter that may allow for increased permeation of taxanes into the brain.
  • $171
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Verapamil hydrochloride
T1010152-11-4
Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.
  • $41
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Agnuside
T386811027-63-7
Agnuside (chasteberry oil) inhibits COX-2 (IC50: 0.026 mg ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-glycoprotein (P-gp) ATPase activity at concentrations of 5, 25, and 100 μM, respectively.
  • $39
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(20S)-Protopanaxadiol
T279930636-90-9
(20S)-Protopanaxadiol (20-Epiprotopanaxadiol) (20-Epiprotopanaxadiol), an apoptosis inducer, is an aglycon metabolic derivative of the protopanaxadiol-type ginseng saponin.
  • $45
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Selamectin
T4059220119-17-5
Selamectin (UK-124114) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. In an H. contortus larval development assay, selamectin (0.1 μg ml) shows the effect of growth inhibition.
  • $31
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Dofequidar fumarate
T11071153653-30-6
Dofequidar fumarate (MS-209)(MS-209 fumarate), a quinoline-based compound administered orally, is known for counteracting multidrug resistance (MDR) through the inhibition of ABCB1/P-glycoprotein (P-gp) and ABCC1/MDR-associated protein 1.
  • $33
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Phellamurin
TN476152589-11-4
Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadministration of Phellamurin or Phellode
  • $166
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Alisol F 24-acetate
TMA2270443683-76-9
Alisol F 24-acetate, a natural product isolated from Alisma plantago-aquatica Linn[1], enhances chemosensitivity and apoptosis of MCF-7 DOX Cells by inhibiting P-Glycoprotein-Mediated drug efflux[2].
  • $179
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Encequidar mesylate
T11578L849675-87-2
Encequidar mesylate (HM30181A mesylate) is a competitive P-glycoprotein inhibitor.
  • $35
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Pristinamycin IA
T125403131-03-1
Pristinamycin IA (Mikamycin B) is a cyclo-peptidic macrolactone antibiotic and a substrate for the P-glycoprotein.
  • $97
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Sinapine thiocyanate
T33927431-77-8
Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800). It is also a phenolic-chloine conjugates, acting as anti-oxidants and acetylcholinesterase inhibitors, that can be used for the treatment of Alzheimer's disease (AD).
  • $55
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Chrysosplenetin
TJS1159603-56-5
Chrysosplenetin is a metabolic inhibitor of artemisinin.
  • $55
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Hernandezine
TN17316681-13-6
Hernandezine is an activator of AMPK activator and a selective reversing agent for ABCB1-mediated MDR in cancer cells.
  • $156
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Convallatoxin
TN1525508-75-8
Convallatoxin is a natural product
  • $132
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Zamicastat
T133831080028-80-3
Zamicastat (BIA 5-1058) is an inhibitor of dopamine β-hydroxylase (DBH) and a concentration-dependent dual inhibitor of P-gp and BCRP, with IC50 values of 73.8 μM and 17.0 μM, respectively.
  • $88
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YS-370
T600092470908-79-1
YS-370 is an orally active inhibitor of P-gp and shows moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance to paclitaxel and colchicine and exhibits stronger antitumor activity in combination with paclitaxel.
  • $58
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HM-30181 mesylate monohydrate
T91732097125-58-9
HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs.
  • $63
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Trifluoperazine dihydrochloride
T1222440-17-5
Trifluoperazine dihydrochloride (SKF5019) is a potent dopamine D2 receptor inhibitor used as an antipsychotic and an antiemetic.
  • $50
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Norverapamil hydrochloride
T1633967812-42-4
Norverapamil hydrochloride (D591 hydrochloride) ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.
  • $31
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Furanodiene
TN165119912-61-9
Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.
  • $52
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Tariquidar methanesulfonate hydrate
T13087625375-83-9
Tariquidar methanesulfonate hydrate (XR9576 methanesulfonate hydrate) is a selective and potent P-glycoprotein drug efflux pump inhibitor with potential anticancer activity that induces P-glycoprotein inhibition of the blood-brain barrier in rats.
  • $30
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P-gp inhibitor 1
T123412050747-49-2
P-gp inhibitor 1 inhibits reversing P-glycoprotein-mediated multidrug resistance with an EC50 of 57.9 nM (K562 A02 cells).
  • $46
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Euphorbia factor L1
T2S041076376-43-7
Euphorbia factor L1 (Euphorbiasteroid) can reduce Bcl-2, PI3K, AKT, and mTOR protein and mRNA levels, and up-regulate caspase-9 and caspase-3 protein levels. It induces autophagy and has anti-cancer, anti-adipogenic, anti-osteoclastogenic, and multidrug-resistant regulatory effects.
  • $100
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7beta-Hydroxylathyrol
T2S201834208-98-5
7β-Hydroxylathyrol is a diterpenoid extract from the seed oil of Caper Spurge and displays P-gp inhibition resulting in cytotoxic properties.
  • $29
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Pafenolol
T6812475949-61-0In house
Pafenolol is a P-glycoprotein modulator with a Ki value of 5.5 µM. pafenolol is an orally available and selective beta-adrenergic receptor antagonist.
  • $86
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Tepotinib hydrochloride(1 : x)
T96011103508-80-0
Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14 skipping mutations.
  • $148
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FM04
T720551807320-40-6In house
FM04 is an orally active and highly potent inhibitor of P-glycoprotein (P-gp) with an EC50 value of 83 nM. FM04 can interact with Q1193 and I1115 in human P-gp nucleotide binding domain 2 (NBD2). Thereby disrupting the R262-Q1081-Q1118 interaction pocket and uncoupling the ICL2-NBD2 interaction, thereby inhibiting P-gp. FM04 can be used in the treatment of cancer and tumors.
  • $195
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P-gb-IN-1
T775752632874-49-6
P-gb-IN-1 is a potent P-glycoprotein (P-gp) inhibitor that exhibits reverse activity by inhibiting P-gp outflow. P-gb-IN-1 has been shown to inhibit P-gp by hydrogen bonding with residues Asn 721 and Met 986. P-gb-IN-1 showed low toxicity in MCF-7/ADR cells.
  • $195
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PGP-4008
T28396365565-02-2In house
PGP-4008 is a selective and potent P-glycoprotein (Pgp) inhibitor that inhibits tumor growth by co-administration with Doxorubicin.
  • $64
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