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4-Methyldaphnetin
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Catalog No. TJS0315Cas No. 2107-77-9
Alias DHMC, 7,8-Dihydroxy-4-methylcoumarin
4-Methyldaphnetin (DHMC) is a potent inhibitor (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radicals, but may be pro-oxidant (enhancing generation of hydroxyl radicals) in the presence of free iron ions.2. 4-Methyldaphnetin(7,8-Dihydroxy-4-methylcoumarin) inhibits the proinflammatory 5-lipoxygenase enzyme at micromolar concentrations.
4-Methyldaphnetin
Copy Product Info🥰Excellent
Purity: 99.73%
Catalog No. TJS0315Alias DHMC, 7,8-Dihydroxy-4-methylcoumarinCas No. 2107-77-9
4-Methyldaphnetin (DHMC) is a potent inhibitor (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radicals, but may be pro-oxidant (enhancing generation of hydroxyl radicals) in the presence of free iron ions.2. 4-Methyldaphnetin(7,8-Dihydroxy-4-methylcoumarin) inhibits the proinflammatory 5-lipoxygenase enzyme at micromolar concentrations.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 mg | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.73%
Appearance:Solid
Color:White
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Product Introduction
4-Methyldaphnetin AI Summary
4-Methyldaphnetin exhibits a diverse range of bioactivities across several assays. It shows moderate inhibition of AFB1 binding to DNA in rat liver microsomes, with inhibition percentages ranging from 8.2% to 8.9% and displays a weak activation effect on the transacetylase catalyzed activation of NADPH cytochrome C reductase (2.5% to 3.5%). Notably, 4-Methyldaphnetin induces apoptosis in human U937 cells with an activity level of 55.0% at 250 µM after 24 hours and manifests cytotoxicity with a CC50 of 165,400.0 nM after 48 hours, along with growth inhibition (IC50 of 48,650.0 nM). It also inhibits alpha-glucosidase activity with IC50 values around 52,700.0 nM. The compound further demonstrates antioxidant activity, as shown by the FRAP test and DPPH radical scavenging activity, with various IC50 values indicating its capacity to neutralize free radicals.
4-Methyldaphnetin has significant inhibitory effects on OATP1B1 and OATP1B3 transporters, with inhibition rates of 61.23% and 78.2%, respectively. It displays antiviral activity, notably against Influenza A virus with an IC50 of 91.5 µg/mL and shows inhibition of SARS-CoV-2 induced cytotoxicity in VERO-6 cells with an IC50 greater than 20,000 nM. Additionally, the compound inhibits Mcl-1 protein, having a Ki value of 2110.0 nM and an IC50 value of 11,210.0 nM.
Moreover, 4-Methyldaphnetin demonstrates inhibitory effects on several enzymatic and cellular targets, including rat lens aldose reductase (IC50 of 10,000.0 nM), alpha-glucosidase (IC50 values approximately 52,000.0 nM), as well as several other proteins and pathways such as Lamin A splicing, Human Jumonji Domain Containing 2E, Tau fibril formation, and ERK signaling pathway. It also acts as a modulator of vitamin D receptor, ROR gamma transcriptional activity, and has cytotoxic effects on cancer cells with p53 mutations.
These multifaceted bioactivities suggest that 4-Methyldaphnetin holds potential therapeutic implications across a spectrum of diseases, including oxidative stress-related conditions, viral infections, enzymatic dysregulations, and various forms of cancer..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 4-Methyldaphnetin (DHMC) is a potent inhibitor (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radicals, but may be pro-oxidant (enhancing generation of hydroxyl radicals) in the presence of free iron ions.2. 4-Methyldaphnetin(7,8-Dihydroxy-4-methylcoumarin) inhibits the proinflammatory 5-lipoxygenase enzyme at micromolar concentrations. |
| Synonyms | DHMC, 7,8-Dihydroxy-4-methylcoumarin |
| Molecular Weight | 192.17 |
| Formula | C10H8O4 |
| Cas No. | 2107-77-9 |
| Smiles | Cc1cc(=O)oc2c(O)c(O)ccc12 |
| Relative Density. | 1.456g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 35 mg/mL (182.13 mM), Sonication is recommended. Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (10.41 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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