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DDR1-IN-4

Name: DDR1-IN-4
Brand: TargetMol
SKU: T39572
Price: 215 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39572Cas No. 2125676-13-1

DDR1-IN-4 (Compound 2.45) is a highly potent inhibitor that selectively targets Discoidin Domain Receptor 1 (DDR1) autophosphorylation, demonstrating exceptional efficacy with IC50 values of 29 nM for DDR1 and 1.9 μM for DDR2.

DDR1-IN-4

🥰Excellent

Purity: 97.25%

Catalog No. T39572Cas No. 2125676-13-1

Pack Size	Price	Availability
1 mg	$215	In Stock
5 mg	$538	In Stock
10 mg	$868	In Stock
25 mg	$1,730	In Stock
50 mg	$2,820	In Stock
100 mg	$4,560	In Stock

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Purity:97.25%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	DDR1-IN-4 (Compound 2.45) is a highly potent inhibitor that selectively targets Discoidin Domain Receptor 1 (DDR1) autophosphorylation, demonstrating exceptional efficacy with IC50 values of 29 nM for DDR1 and 1.9 μM for DDR2.
Targets&IC50	DDR2:1900 nM, DDR1:29 nM
In vitro	DDR1-IN-4 (Compound 2.45) exhibits dose-dependent inhibition of DDR1 phosphorylation in DDR1-overexpressing HT1080 cells, achieving over 70% inhibition at a 1 μM concentration, while maintaining selectivity against DDR2 [1].
In vivo	DDR1-IN-4 (Compound 2.45, ip, 90 mg/kg) maintains renal function and mitigates tissue damage in Col4a3 –/– mice, a preclinical model for Alport syndrome, through DDR1 phosphorylation inhibition. In this model, daily 90 mg/kg intraperitoneal injections reduced fibrosis, indicated by Picro Sirius Red, smooth muscle actin staining, collagen I levels, and decreased pDDR1 levels, demonstrating efficacy.

Chemical Properties

Molecular Weight	565.34
Formula	C₂₃H₂₀BrF₃N₆O₃
Cas No.	2125676-13-1
Smiles	O=C(NCC(F)(F)F)CN1C(=O)C2(C=3C(Br)=CC=CC31)CCN(C(=O)C4=NC=5C=NNC5C=C4)CC2
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (353.77 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7688 mL	8.8442 mL	17.6885 mL	88.4424 mL
5 mM	0.3538 mL	1.7688 mL	3.5377 mL	17.6885 mL
10 mM	0.1769 mL	0.8844 mL	1.7688 mL	8.8442 mL
20 mM	0.0884 mL	0.4422 mL	0.8844 mL	4.4221 mL
50 mM	0.0354 mL	0.1769 mL	0.3538 mL	1.7688 mL
100 mM	0.0177 mL	0.0884 mL	0.1769 mL	0.8844 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc